CAS No.: 223645-67-8
(S)-4-Fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline Catalog No. CSN16953
Synonyms: K-115 (free base);Ripasudil Free Base;K 115 Free Base
K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00176020 Healthy Phase 1 Unknown - - NCT01258491 Healthy Subjects Phase 1 Completed - - NCT03575130 Fuchs' Endothelial Dystrophy ... more >> Fuchs Dystrophy Corneal Endothelial Dystrophy Corneal Endothelial Cell Loss Cornea Guttata Collapse << Phase 2 Recruiting December 31, 2018 Germany ... more >> Department of Ophthalmology, University of Erlangen-Nürnberg Recruiting Erlangen, Germany, 91054 Contact: Friedrich E Kruse, Prof. +49913185 ext 34477 friedrich.kruse@uk-erlangen.de Collapse << - 更多
- 参考文献
- [1] Kaneko Y, Ohta M, et al. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640.
- [2] Yamamoto K, Maruyama K, et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55(11):7126-36.
实验方案
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技术信息
| CAS号 | 223645-67-8 | 储存条件 |
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| 分子式 | C15H18FN3O2S | 运输 | 蓝冰 | |
| 分子量 | 323.39 | 别名 | K-115 (free base);Ripasudil Free Base;K 115 Free Base;K-115 (free base |
