|(S)-3-异丙基-6-((1-苯基乙基)氨基)嘧啶-2,4(1H,3H)-二酮|CsnPharm

CAS No.: 1642288-47-8

(S)-3-Isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione Catalog No. CSN20537

Synonyms: MYK461;SAR439152

MYK-461 is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy, and can reduce contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述MYK-461 is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy, and can reduce contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03442764	Non-obstructive Hypertrophic C... more >>ardiomyopathy Collapse <<	Phase 2	Recruiting	July 2019	-
NCT03723655	Hypertrophic Cardiomyopathy	Phase 2 Phase 3	Enrolling by invitation	June 2022	United States, Oregon ... more >> Oregon Health & Sciences University Portland, Oregon, United States, 97239 Collapse <<
NCT03470545	Obstructive Hypertrophic Cardi... more >>omyopathy Collapse <<	Phase 3	Recruiting	June 2020	-

更多
参考文献

[1] Kawas RF, Anderson RL, et al. A small molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Aug 14. pii: jbc.M117.776815.
[2] Green EM, Wakimoto H, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6586 mL
- 18.2929 mL
- 36.5858 mL
- 5 mM
- 0.7317 mL
- 3.6586 mL
- 7.3172 mL
- 10 mM
- 0.3659 mL
- 1.8293 mL
- 3.6586 mL

技术信息

CAS号	1642288-47-8	储存条件	粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H19N3O2	运输	蓝冰
分子量	273.33	别名	MYK461;SAR439152

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03442764	Non-obstructive Hypertrophic C... more >>ardiomyopathy Collapse <<	Phase 2	Recruiting	July 2019	-
NCT03723655	Hypertrophic Cardiomyopathy	Phase 2 Phase 3	Enrolling by invitation	June 2022	United States, Oregon ... more >> Oregon Health & Sciences University Portland, Oregon, United States, 97239 Collapse <<
NCT03470545	Obstructive Hypertrophic Cardi... more >>omyopathy Collapse <<	Phase 3	Recruiting	June 2020	-
NCT02329184	Hypertrophic Cardiomyopathy	Phase 1	Completed	-	United States, Arizona ... more >> Scottsdale, Arizona, United States, 85259 United States, California Cypress, California, United States, 90630 Stanford, California, United States, 94305 United States, Massachusetts Boston, Massachusetts, United States, 02111 United States, Michigan Kalamazoo, Michigan, United States, 49007 United States, North Carolina Durham, North Carolina, United States, 27710 United States, Tennessee Nashville, Tennessee, United States, 37232 Collapse <<
NCT03496168	Hypertrophic Cardiomyopathy	Phase 2	Recruiting	June 2020	United States, Arizona ... more >> Mayo Clinic Arizona, Mayo Clinic Scottsdale Recruiting Scottsdale, Arizona, United States, 85259 Principal Investigator: Steven Heitner, MD United States, Connecticut Yale New Haven Hospital Recruiting New Haven, Connecticut, United States, 06511 Principal Investigator: Daniel Jacoby, MD United States, North Carolina Duke Cardiology at Southpoint Recruiting Durham, North Carolina, United States, 27713 Principal Investigator: Andrew Wang, MD United States, Oregon Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239 Principal Investigator: Stephen Heitner, MD Collapse <<
NCT02356289	Healthy	Phase 1	Completed	-	United Kingdom ... more >> Quintles LTD London, United Kingdom Collapse <<
NCT02480296	Healthy	Phase 1	Completed	-	Australia, Victoria ... more >> Nucleus Network Melbourne, Victoria, Australia Collapse <<
NCT02842242	Cardiomyopathy, Hypertrophic O... more >>bstructive Collapse <<	Phase 2	Completed	-	United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States United States, Connecticut Yale New Haven Hospital New Haven, Connecticut, United States United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States United States, Missouri Washington University St. Louis Saint Louis, Missouri, United States United States, North Carolina Duke Health Center at Southpoint Durham, North Carolina, United States United States, Oregon Oregon Health and Science University Portland, Oregon, United States United States, Pennsylvania Hospital of the University of Pennsylvania (Penn Heart and Vascular Center) Philadelphia, Pennsylvania, United States Collapse <<

(S)-3-Isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione Catalog No. CSN20537

靶点选择性

请登录您的专属账户

确认信息