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CAS No.: 19879-30-2

补骨脂二氢黄酮甲醚 Catalog No. CSN10380

Synonyms: 7-O-Methylbavachin;Bavachinin A;补骨脂二氢黄酮甲醚

Bavachinin is an agonist of PPAR with EC50s of 4.0 µM, 8.1 µM, and 0.74 µM for α,β/δ, and γ respectively. It is a natural flavanone with anti-angiogenic effect.

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技术信息

生物活性

描述Bavachinin (BVC) is a natural product derived from the fruit of the traditional Chinese herb Fructus Psoraleae (FP). BVC induces HepaRG cell death via ROS and the JNK/p38 signaling pathways^[3]. BVC (bavachinin) exhibited glucose-lowering properties without inducing weight gain and hepatotoxicity. Importantly, BVC synergised with thiazolidinediones, which are synthetic PPAR-γ (Pan-peroxisome proliferator-activated receptor) agonists, and fibrates, which are PPAR-α agonists, to induce PPAR transcriptional activity, as well as to lower glucose and triacylglycerol levels in db/db mice^[4]. The survival rates and cell viability of A549 cells were reduced by BNN (Bavachinin) in a dose‑dependent manner. BNN dose‑dependently changed the expression of Bcl‑2, Bax, caspases‑3/9 and PPARγ^[5]. In vivo studies showed that injecting Bavachinin thrice weekly for four weeks significantly reduced tumor volume and CD31 expression in nude mice with KB xenografts^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9551 mL
- 14.7755 mL
- 29.5511 mL
- 5 mM
- 0.5910 mL
- 2.9551 mL
- 5.9102 mL
- 10 mM
- 0.2955 mL
- 1.4776 mL
- 2.9551 mL

技术信息

CAS号

19879-30-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22O4

运输

蓝冰

分子量

338.40

别名

7-O-Methylbavachin;Bavachinin A;补骨脂二氢黄酮甲醚

溶解度

DMSO	67.0 mg/mL (198.0 mM)

动物实验配方

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