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CAS No.: 98625-26-4

(S)-(-)-Bay-K-8644 Catalog No. CSN18644

Synonyms: (S)-(−)-BAY-K-8644

Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).

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生物活性

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技术信息

生物活性

描述(S) -(-)-Bay K 8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM). (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum^[3]. The channel activity was enhanced by 3-30 microM S(-)Bay K 8644, an agonist of L-type Ca2+ channels^[4]. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50=14 nM). (S)-Bay K 8644 (100 nM) increased whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocked further stimulation by 1 microM FPL 64176^[5]. S-(-)-Bay K 8644 failed to produce characteristically large increases in current when cells were held at -40 mV and Ca2+ was used as the charge carrier, although high-affinity binding and the effects of the antagonist isomer, R-(+)-Bay K 8644, were intact. The pharmacology of S-(-)-Bay K 8644 in stem cell-derived cardiomyocytes varies by cell type, is unusually dependent on holding potential and charge carrier, and is different from that observed in primary human heart cells^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8067 mL
- 14.0333 mL
- 28.0665 mL
- 5 mM
- 0.5613 mL
- 2.8067 mL
- 5.6133 mL
- 10 mM
- 0.2807 mL
- 1.4033 mL
- 2.8067 mL

技术信息

CAS号

98625-26-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H15F3N2O4

运输

蓝冰

分子量

356.30

别名

(S)-(−)-BAY-K-8644

溶解度

DMSO	180.0 mg/mL (505.2 mM)
Water	insoluble

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(S)-(-)-Bay-K-8644 Catalog No. CSN18644

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