|4-((9H-嘌呤-6-基)氨基)-1-苄基吡咯烷-2-酮|CsnPharm

CAS No.: 1333714-43-4

(Rac)-Benpyrine Catalog No. CSN27597

Synonyms: rac-Benpyrine;Benpyrine racemate

(Rac)-Benpyrine is the racemate form of Benpyrine. Benpyrine could directly bind to TNF-α and block TNF-α-trigged signaling activation in vitro and in vivo. Administration of benpyrine by gavage significantly relieved the symptoms of collagen-induced arthritis and imiquimod-induced psoriasiform inflammation in mice.

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描述(Rac)-Benpyrine is the racemate form of Benpyrine. Benpyrine could directly bind to TNF-α and block TNF-α-trigged signaling activation in vitro and in vivo. Administration of benpyrine by gavage significantly relieved the symptoms of collagen-induced arthritis and imiquimod-induced psoriasiform inflammation in mice.
参考文献

[1] Sun W, Wu Y, Zheng M, Yang Y, Liu Y, Wu C, Zhou Y, Zhang Y, Chen L, Li H. Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor. J Med Chem. 2020 Aug 13;63(15):8146-8156. doi: 10.1021/acs.jmedchem.0c00377. Epub 2020 Jul 30. PMID: 32667202.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2432 mL
- 16.2160 mL
- 32.4320 mL
- 5 mM
- 0.6486 mL
- 3.2432 mL
- 6.4864 mL
- 10 mM
- 0.3243 mL
- 1.6216 mL
- 3.2432 mL

技术信息

CAS号	1333714-43-4	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H16N6O	运输	蓝冰
分子量	308.34	别名	rac-Benpyrine;Benpyrine racemate

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