|(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺盐酸盐|CsnPharm

CAS No.: 123464-89-1

(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride Catalog No. CSN17602

Synonyms: PNU-282,987

PNU-282987 is a selective α7 nAChR agonist with ki value of 26nM and displays almost no effect on α1β1γδ and α3β4 nAChRs.

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技术信息

生物活性

描述PNU-282987 is a selective α7 nicotinic acetylcholine receptor (α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM)^[2]. Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion^[3]. PNU-282987 treatment, either before or after ALI induction, reduced neutrophil recruitment and IL-1β, TNF-α, IL-6, keratinocyte chemoattractant (KC), and IL-10 cytokine levels in the bronchoalveolar lavage fluid. PNU-282987 treatment also reduced lung mRNA levels and the frequency of M1 macrophages, whereas cells expressing the M2-related markers CD206 and IL-10 increased, suggesting changes in the macrophage profile^[4]. Mice treated with 2.5 and 10 mg/kg of PNU-282987 devoted less time to rearing into open arms. In the HB task, MC(Marlau™ cages) mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE (environmental enrichment) and SE (standard environment), whereas EE displayed low exploration levels reflected in total HD (head-dips) (5 min)^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3199 mL
- 16.5996 mL
- 33.1993 mL
- 5 mM
- 0.6640 mL
- 3.3199 mL
- 6.6399 mL
- 10 mM
- 0.3320 mL
- 1.6600 mL
- 3.3199 mL

技术信息

CAS号

123464-89-1

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H18Cl2N2O

运输

蓝冰

分子量

301.21

别名

PNU-282,987

溶解度

DMSO	46.0 mg/mL (152.7 mM)
Water	10.0 mg/mL (33.2 mM)
Ethanol	4.0 mg/mL (13.3 mM)

动物实验配方

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(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride Catalog No. CSN17602

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