|(R)-2-氨基-4-(甲巯基)丁酸|CsnPharm

CAS No.: 348-67-4

D-蛋氨酸 Catalog No. CSN23642

Synonyms: MRX-1024;D-Methionine;H-D-Met-OH

MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss. It can used as a chemoprotective agent.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述MRX-1024(Methionine; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation. The antioxidants L-carnitine and D-methionine modulate cortical electrical spike activity primarily through GABAA receptor activation^[1]. Oral MRX-1024 resulted in rapid and dose-dependent increases in plasma D-met concentrations with a half-life of 3 hours. There is a dose-dependent increase in D-met exposure following MRX-1024 administration at 50 and 100 mg/kg, and MRX-1024 is safe for use concurrent with combined radiation and chemotherapy^[2]. Moreover, the antioxidant D-methionine protects against cisplatin-induced ototoxicity and nephrotoxicity. D-methionine prevents the dramatic cisplatin-induced decrease of neurogenesis^[3].
参考文献

[1] Wu C, Gopal KV, Moore EJ, Gross GW. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93
[2] Hamstra DA, Eisbruch A, Naidu MU, Ramana GV, Sunkara P, Campbell KC, Ross BD, Rehemtulla A. Pharmacokinetic analysis and phase 1 study of MRX-1024 in patients treated with radiation therapy with or without cisplatinum for head and neck cancer. Clin Cancer Res. 2010 May 1;16(9):2666-76
[3] Hinduja S, Kraus KS, Manohar S, Salvi RJ. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27(3):199-204

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.7019 mL
- 33.5095 mL
- 67.0191 mL
- 5 mM
- 1.3404 mL
- 6.7019 mL
- 13.4038 mL
- 10 mM
- 0.6702 mL
- 3.3510 mL
- 6.7019 mL

技术信息

CAS号

348-67-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H11NO2S

运输

蓝冰

分子量

149.21

别名

MRX-1024;D-Methionine;H-D-Met-OH;D-蛋氨酸

溶解度

DMSO	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

D-蛋氨酸 Catalog No. CSN23642

靶点选择性

请登录您的专属账户

确认信息