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CAS No.: 52-90-4

L-半胱氨酸 Catalog No. CSN23419

Synonyms: L-半胱氨酸

L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述L-Cysteine is a nutritionally semiessential amino acid and is present mainly in the form of L-cystine in the extracellular space. With the help of a transport system, extracellular L-cystine crosses the plasma membrane and is reduced to L-cysteine within cells by thioredoxin and reduced glutathione (GSH). Intracellular L-cysteine plays an important role in cellular homeostasis as a precursor for protein synthesis, and for production of GSH, hydrogen sulfide (H(2)S), and taurine^[1]. L-Cysteine, an H2S donor, significantly alleviated brain injury after hypoxia-ischemic (HI) injury in neonatal mice. L-Cysteine attenuated the accumulation of CD11b+/CD45 high cells, activation of microglia and astrocytes and diminished HI-induced increases in reactive oxygen species and malondialdehyde within the lesioned cortex. In addition, L-Cysteine increased microtubule associated protein 1 light chain 3-II and Beclin1 expression, decreased p62 expression and phosphor-mammalian target of rapamycin and phosphor-signal transducer and activator of transcription 3^[2]. In addition, overexpression of NCgl2566 and NCgl0580 resulted in enhanced L-cysteine production in an L-cysteine-producing recombinant strain of C. glutamicum^[3].
参考文献

[1] Yin J, Ren W, Yang G, et al. L-Cysteine metabolism and its nutritional implications. Mol Nutr Food Res. 2016;60(1):134-146
[2] Xin D, Chu X, Bai X, et al. l-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation. Brain Behav Immun. 2018;73:222-234
[3] Kishino M, Kondoh M, Hirasawa T. Enhanced L-cysteine production by overexpressing potential L-cysteine exporter genes in an L-cysteine-producing recombinant strain of Corynebacterium glutamicum. Biosci Biotechnol Biochem. 2019;83(12):2390-2393

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 8.2537 mL
- 41.2684 mL
- 82.5367 mL
- 5 mM
- 1.6507 mL
- 8.2537 mL
- 16.5073 mL
- 10 mM
- 0.8254 mL
- 4.1268 mL
- 8.2537 mL

技术信息

CAS号

52-90-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C3H7NO2S

运输

蓝冰

分子量

121.16

别名

L-半胱氨酸

溶解度

Water

30.0 mg/mL (247.6 mM) warming

动物实验配方

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L-半胱氨酸 Catalog No. CSN23419

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