|(R)-2-(2-((R)-1-(4-氯苯基)-1-苯乙氧基)乙基)-1-甲基吡咯烷富马酸盐|CsnPharm

CAS No.: 14976-57-9

富马酸氯马斯汀 Catalog No. CSN10663

Synonyms: HS-592 fumarate;Meclastine fumarate;Mecloprodine

Clemastine fumarate is a selective antagonist of histamine H1 receptor with IC50 of 3 nM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Histamine Receptor H1

IC50:3nM
描述Clemastine Fumarate is a first-generation histamine receptor H1 (HRH1) antagonist. As a safe and efficient anti-allergic agent, clemastine could impressively alleviate stress-related depressive-like phenotype in mice^[3]. Clemastine fumarate can stimulate differentiation of oligodendrocyte precursor cells in vitro, in animal models, and in human cells^[4]. Clemastine fumarate (CLE) can protect against myocardial ischemia-reperfusion injury (MIRI) through regulation of toll like receptor 4 (TLR4)^[5]. Clemastine, failed to prevent migraine or headache after pituitary adenylate cyclase activating peptide-38 infusion, thus making a role for histamine release or mast cell degranulation in pituitary adenylate cyclase activating peptide-38-induced migraine less likely^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01154361	Angioedema	Phase 2	Completed	-	Germany ... more >> Klinikum rechts der Isar Hals-Nasen-Ohrenklinik der TUM Munich, Bavaria, Germany, 81675 Collapse <<
NCT00481676	-	-	Completed	-	-
NCT01125761	Dermatitis	Phase 3	Withdrawn	-	Brazil ... more >> LAL Clinica Pesquisa e Desenvolvimento Ltda Valinhos, São Paulo, Brazil, 13276-245 LAL Clínica Pesquisa e Desenvolvimento Ltda Valinhos, São Paulo, Brazil, 13276-245 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1741 mL
- 10.8705 mL
- 21.7410 mL
- 5 mM
- 0.4348 mL
- 2.1741 mL
- 4.3482 mL
- 10 mM
- 0.2174 mL
- 1.0871 mL
- 2.1741 mL

技术信息

CAS号

14976-57-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H30ClNO5

运输

蓝冰

分子量

459.96

别名

HS-592 fumarate;Meclastine fumarate;Mecloprodine;Clemastine (fumarate);Clemastine Fumarate;Tavist;Agasten;Aloginan;Clemastine;HS-592;Meclastine;Mecloprodin;Tavegyl;富马酸氯马斯汀

溶解度

DMSO	35.0 mg/mL (76.1 mM) warming
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01154361	Angioedema	Phase 2	Completed	-	Germany ... more >> Klinikum rechts der Isar Hals-Nasen-Ohrenklinik der TUM Munich, Bavaria, Germany, 81675 Collapse <<
NCT00481676	-	-	Completed	-	-
NCT01125761	Dermatitis	Phase 3	Withdrawn	-	Brazil ... more >> LAL Clinica Pesquisa e Desenvolvimento Ltda Valinhos, São Paulo, Brazil, 13276-245 LAL Clínica Pesquisa e Desenvolvimento Ltda Valinhos, São Paulo, Brazil, 13276-245 Collapse <<
NCT00913549	Allergy	Phase 1	Completed	-	-
NCT02613091	Healthy Subjects	Phase 1	Completed	-	United States, California ... more >> Sandler Neurosciences Building, Neurological Clinical Research Unit San Francisco, California, United States, 94107 Collapse <<
NCT00481676	Chronic Urticaria	Phase 2	Completed	-	Germany ... more >> Novartis Investigative Site Berlin, Germany Novartis Investigative Site Bonn, Germany Novartis Investigative Site Dresden, Germany Novartis Investigative Site Giessen, Germany Novartis Investigative Site Hamburg, Germany Novartis Investigative Site Hannover, Germany Novartis Investigative Site Koeln, Germany Novartis Investigative Site Leipzig, Germany Novartis Investigative Site Luebeck, Germany Novartis Investigative Site Mainz, Germany Novartis Investigative Site Munich, Germany Collapse <<
NCT02521311	Optic Neuritis	Phase 2	Recruiting	January 2021	United States, California ... more >> University of California San Francisco Recruiting San Francisco, California, United States, 94158 Contact: Tracy Tran, BA 415-353-2707 tracy.tran@ucsf.edu Collapse <<
NCT02040298	Multiple Sclerosis, Relapsing-... more >>Remitting Collapse <<	Phase 2	Completed	-	United States, California ... more >> UCSF Multiple Sclerosis Center San Francisco, California, United States, 94518 Collapse <<
NCT01239719	Allergy Derma... more >>titis Collapse <<	Phase 3	Unknown	December 2011	-
NCT01257061	Eczema	Phase 3	Unknown	August 2013	Brazil ... more >> Medcin instituto da Pele Recruiting Osasco, São Paulo, Brazil, 060323-000 Contact: Flavia Addor 5511 3681 6362 Collapse <<

富马酸氯马斯汀 Catalog No. CSN10663

靶点选择性

请登录您的专属账户

确认信息