|E-2-氰基-3-(3,4-二羟基苯基)丙烯酰胺|CsnPharm

CAS No.: 122520-85-8

(E)-AG 99 Catalog No. CSN23735

Synonyms: (E)-Tyrphostin 46;(E)-Tyrphostin AG 99;Tyrphostin 46

AG 99 is an EGF receptor kinase inhibitor with IC50 of 10 µM in the human epidermoid carcinoma cell line A431.

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400-920-2911

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技术信息

生物活性

描述Epidermal Growth Factor Receptor (EGFR) is a transmembrane glycoprotein that constitutes one of the four members of ErbB family of tyrosine kinase receptors. Activation of EGFR leads to autophosphorylation of receptor tyrosine kinase that initiates a cascade of downstream signaling pathways involved in regulating cellular proliferation, differentiation, and survival. EGFR is abnormally activated by various mechanisms like receptor overexpression, mutation, ligand-dependent receptor dimerization, ligand-independent activation and is associated with the development of variety of human cancers. AG99 (α-cyano-(3,4-dihydroxy)cinnamide) is a potent EGFR inhibitor. It effectively blocks tyrosine phosphorylation of p145^met and promotes cell death accompanied by activation of caspase-like proteases. AG99 was shown to inhibit the appearance of pp145 (145-kDa protein) to some extent. It also showed a growth-inhibitory effect on not only serum-starved cells but also normally grown cells, which suggested, therefore, that the importance of EGFR is not limited to serum-independent growth and/or the EGFR inhibitor has an alternative target to exert its growth-inhibitory effect in normally grown cells.
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.8976 mL
- 24.4882 mL
- 48.9764 mL
- 5 mM
- 0.9795 mL
- 4.8976 mL
- 9.7953 mL
- 10 mM
- 0.4898 mL
- 2.4488 mL
- 4.8976 mL

技术信息

CAS号

122520-85-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H8N2O3

运输

蓝冰

分子量

204.18

别名

(E)-Tyrphostin 46;(E)-Tyrphostin AG 99;Tyrphostin 46;Tyrphostin AG-99;AG-99

溶解度

DMSO	41.0 mg/mL (200.8 mM)
Water	Insoluble
Ethanol	Insoluble

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