|(E)-4-(3,5-二甲氧基苯乙烯基)苯酚|CsnPharm

CAS No.: 537-42-8

紫檀芪 Catalog No. CSN11797

Synonyms: 紫檀茋;3',5'-Dimethoxy Resveratrol;3',5'-Dimethoxy-4-Stilbenol

Pterostilbene is a natural dietary compound with antioxidant, antiproliferative, antihyperglycemic and antidiabetic effect, and is also an apoptosis inducer.

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生物活性

实验方案

技术信息

生物活性

描述Pterostilbene is a naturally dimethylated analog of resveratrol. Pterostilbene act as an antioxidant by reducing oxidative stress and increasing the endogenous antioxidant level. After oral administration of suspension (15 mg/kg), pterostilbene tended to have lower Cmax but higher plasma exposure (AUC)^[3]. Pterostilbene inhibited mitogen‐activated protein kinase (MAPK) activation and the production of pro‐inflammatory cytokine in lipopolysaccharides (LPS)‐activated microglia^[4]. Impaired cognitive functions could be improved by pterostilbene administration.Furthermore, pterostilbene reduced the gene expression of inflammatory mediators^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02819219	Healthy	Not Applicable	Completed	-	-
NCT02678611	Safety: Healthy Subjects	Phase 1	Completed	-	Canada, Ontario ... more >> KGK Synergize Inc. London, Ontario, Canada, N6A 5R8 Collapse <<
NCT02998918	Inflammation ... more >>Atherosclerosis Cardiovascular Disease Collapse <<	Phase 2	Recruiting	December 2018	United States, South Carolina ... more >> Clinical Exercise Research Center Recruiting Columbia, South Carolina, United States, 29201 Contact: Sarah Schumacher 803-777-3331 dickeysc@mailbox.sc.edu Principal Investigator: Mark Sarzynski, PhD Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9017 mL
- 19.5087 mL
- 39.0173 mL
- 5 mM
- 0.7803 mL
- 3.9017 mL
- 7.8035 mL
- 10 mM
- 0.3902 mL
- 1.9509 mL
- 3.9017 mL

技术信息

CAS号	537-42-8	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H16O3	运输	蓝冰
分子量	256.30	别名	紫檀茋;3',5'-Dimethoxy Resveratrol;3',5'-Dimethoxy-4-Stilbenol;trans-3,5-Dimethoxy-4'-Hydroxystilbene

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02819219	Healthy	Not Applicable	Completed	-	-
NCT02678611	Safety: Healthy Subjects	Phase 1	Completed	-	Canada, Ontario ... more >> KGK Synergize Inc. London, Ontario, Canada, N6A 5R8 Collapse <<
NCT02998918	Inflammation ... more >>Atherosclerosis Cardiovascular Disease Collapse <<	Phase 2	Recruiting	December 2018	United States, South Carolina ... more >> Clinical Exercise Research Center Recruiting Columbia, South Carolina, United States, 29201 Contact: Sarah Schumacher 803-777-3331 dickeysc@mailbox.sc.edu Principal Investigator: Mark Sarzynski, PhD Collapse <<
NCT03176628	Acute Kidney Injury	Not Applicable	Recruiting	October 31, 2018	United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02118 Contact: Petra Simic, MD, PhD 617-724-6700 psimic@bwh.harvard.edu Contact: Katherine E Brock, BS 617-643-9463 kbrock2@mgh.harvard.edu Principal Investigator: Eugene Rhee, MD Sub-Investigator: Ravi I Thadhani, MD, MPH Sub-Investigator: Petra Simic, MD, PhD Collapse <<
NCT03370991	Menopause Ele... more >>vated Blood Pressure Hypertension Endothelial Dysfunction Collapse <<	Phase 2 Phase 3	Recruiting	December 31, 2019	United States, Colorado ... more >> Department of Food Science and Human Nutrition, Colorado State University Recruiting Fort Collins, Colorado, United States, 80523-1571 Contact: Nicole S. Litwin, MS, RD 970-491-0464 Nicole.Litwin@colostate.edu Contact: Sarah A. Johnson, PhD, RDN (970) 491-3807 Sarah.Johnson@colostate.edu Collapse <<
NCT03754842	Muscle Injury	Not Applicable	Not yet recruiting	July 1, 2020	-
NCT01267227	Hyperlipidemia ... more >> Blood Pressure Oxidative Stress Collapse <<	Phase 2 Phase 3	Completed	-	United States, Mississippi ... more >> University of Mississippi Medical Center Jackson, Mississippi, United States, 39216 Collapse <<
NCT03671811	Endometrial Carcinoma	Phase 2	Recruiting	December 7, 2020	United States, California ... more >> City of Hope Medical Center Recruiting Duarte, California, United States, 91010 Contact: Thanh H. Dellinger, MD 626-218-1379 tdellinger@coh.org Principal Investigator: Thanh H. Dellinger, MD Collapse <<
NCT03635411	Recovery of Function	Phase 1	Not yet recruiting	January 2020	-
NCT01267227	-	-	Completed	-	-

紫檀芪 Catalog No. CSN11797

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