|(E)-3-(3-溴-4,5-二羟基苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺|CsnPharm

CAS No.: 1384426-12-3

(E)-3-(3-Bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Catalog No. CSN15820

Synonyms: NT157

NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 IRS-1

IC50:0.3μM-0.8μM IRS-2

IC50:0.3μM-0.8μM
描述NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro. These effects were correlated with decreased proliferation and increasing apoptosis of LNCaP cells and increasing G2-M arrest in PC3 cells. NT157 can mediate suppression of IGF1R-mediated survival signaling through the established mechanism for negative feedback of IGF1R signaling: targeting IRS1/2 for serine phosphorylation and subsequent degradation. NT157 displayed little to no effect on the survival of normal melanocytes and fibroblasts.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4257 mL
- 12.1284 mL
- 24.2568 mL
- 5 mM
- 0.4851 mL
- 2.4257 mL
- 4.8514 mL
- 10 mM
- 0.2426 mL
- 1.2128 mL
- 2.4257 mL

技术信息

CAS号	1384426-12-3	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H14BrNO5S	运输	蓝冰
分子量	412.26	别名	NT157

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靶点	Description	IC50
IRS-1		IC50:0.3μM-0.8μM
IRS-2		IC50:0.3μM-0.8μM

(E)-3-(3-Bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Catalog No. CSN15820

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