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CAS No.: 2883-98-9

α-细辛脑 Catalog No. CSN11493

Synonyms: α-细辛脑;α-Asarone;trans-Asarone

alpha-Asarone is a naturally occuring inhibitor of both HMG-CoA reductase (IC50 = 3 mM) and certain isoforms of the cytochrome P450 superfamily of enzymes (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively), with neuroprotective, anti-oxidative, anticonvulsive and cognitive enhancing action.

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生物活性

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技术信息

生物活性

描述Alpha-Asarone is a major bioactive component isolated from Acorus gramineus, an herbal medicine that possesses anti-oxidant, anti-hyperlipidemic and anti-inflammatory effects. Alpha-Asarone exhibited acetylcholinesterase (AChE) inhibitory effect in a dose dependent manner. The values of 18.5%, 28.9%, and 66.0% were obtained for tested concentrations of 0.25, 0.5, and 1 mg/ml, respectively.in vivo, hyperlocomotion could be alleviated by administration (10 mg/kg for 15 days) of alpha-Asarone in fragile X mental retardation gene (Fmr1) knockout (KO) mice, which had observable disturbances in the striatal cholinergic system^[3].
参考文献

[1] Park SH, Paek JH, et al. Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages. Int J Mol Med. 2015 Apr;35(4):957-65.
[2] Lee B, Sur B, et al. Alpha-Asarone, a Major Component of Acorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process. Korean J Physiol Pharmacol. 2014 Jun;18(3):191-200.
[3] Qiu G, Chen S, Guo J, Wu J, Yi YH. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behav Brain Res. 2016 Oct 1;312:212-8. doi: 10.1016/j.bbr.2016.06.024. Epub 2016 Jun 15. PMID: 27316341.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.8018 mL
- 24.0092 mL
- 48.0184 mL
- 5 mM
- 0.9604 mL
- 4.8018 mL
- 9.6037 mL
- 10 mM
- 0.4802 mL
- 2.4009 mL
- 4.8018 mL

技术信息

CAS号

2883-98-9

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H16O3

运输

蓝冰

分子量

208.25

别名

α-细辛脑;α-Asarone;trans-Asarone;a-细辛醚

溶解度

DMSO	41.0 mg/mL (196.9 mM)

动物实验配方

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