CAS No.: 110311-30-3
(7S,9S)-9-Acetyl-9-amino-7-(((2S,4S,5R)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride Catalog No. CSN17465
Synonyms: AMR HCl
Amrubicin HCl is a topoisomerase II inhibitor used in the treatment of lung cancer.
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靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00675831 Hematologic Malignancies Phase 1 Completed - United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << NCT03253068 Small Cell Lung Cancer Extensi... more >>ve Stage Collapse << Phase 2 Recruiting August 31, 2020 Japan ... more >> Wakayama Medical University Recruiting Wakayama, Japan, 641-8509 Contact: Hiroaki Akamatsu, M.D. +81-73-441-0619 h-akamat@wakayama-med.ac.jp Contact: Nobuyuki Yamamoto, M.D., Ph.D. +81-73-441-0619 nbyamamo@wakayama-med.ac.jp Collapse << NCT02481830 Lung Cancer Phase 3 Active, not recruiting November 30, 2019 - - 更多
- 参考文献
- [1] Ohmori H, Tsushima T, et al. [Experimental studies on intravesical instillation of SM-5887, a novel anthracycline derivative for treatment of bladder carcinoma] . Gan To Kagaku Ryoho. 1996 Apr;23(5):601-6. Japanese.
- [2] Ueoka H, Ohnoshi T, et al. [New anthracycline analogues in the treatment of lung cancer] . Gan To Kagaku Ryoho. 1992 Nov;19(13):2146-9.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 110311-30-3 | 储存条件 |
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| 分子式 | C25H26ClNO9 | 运输 | 蓝冰 | |
| 分子量 | 519.93 | 别名 | AMR HCl |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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| NCT00675831 | Hematologic Malignancies | Phase 1 | Completed | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
| NCT03253068 | Small Cell Lung Cancer Extensi... more >>ve Stage Collapse << | Phase 2 | Recruiting | August 31, 2020 | Japan ... more >> Wakayama Medical University Recruiting Wakayama, Japan, 641-8509 Contact: Hiroaki Akamatsu, M.D. +81-73-441-0619 h-akamat@wakayama-med.ac.jp Contact: Nobuyuki Yamamoto, M.D., Ph.D. +81-73-441-0619 nbyamamo@wakayama-med.ac.jp Collapse << |
| NCT02481830 | Lung Cancer | Phase 3 | Active, not recruiting | November 30, 2019 | - |
| NCT00286169 | Small-cell Lung Cancer | Phase 3 | Terminated | - | Japan ... more >> Chubu Region Site Chubu, Japan Chugoku Region Site Chugoku, Japan Hokkaido Region Site Hokkaido, Japan Kanto Region Site Kanto, Japan Kinki Region Site Kinki, Japan Kyushu Region Site Kyushu, Japan Shikoku Region Site Shikoku, Japan Tohoku Region Site Tohoku, Japan Collapse << |
| NCT01207011 | Lung Cancer | Phase 3 | Completed | - | Japan ... more >> 32 Sites Sites, Japan Collapse << |
| NCT00132054 | Lung Cancer | Phase 1 | Completed | - | Japan ... more >> Gunma Cancer Center Gunma, Japan, 373-0828 National Hospital Organization - Dohoku National Hospital Hokkaido, Japan, 070-0901 Kyoto University Hospital Kyoto, Japan, 606-8501 Osaka Police Hospital Osaka City, Japan, 543-0035 Kitano Hospital Osaka, Japan, 530-8480 Osaka Kosei Nenkin Hospital Osaka, Japan, 553-0003 National Hospital Organization - Osaka National Hospital Osaka, Japan, 591-8555 Collapse << |
| NCT01076504 | Extensive-Stage Small Cell Lun... more >>g Cancer Collapse << | Phase 2 | Completed | - | United States, Arkansas ... more >> Northeast Arkansas Clinic Jonesboro, Arkansas, United States, 72401 United States, Florida Florida Cancer Specialists Fort Myers, Florida, United States, 33901 Watson Clinic Center for Cancer Care and Research Lakeland, Florida, United States, 33805 Florida Hospital Cancer Institute Orlando, Florida, United States, 32804 United States, Georgia Medical Oncology Associates of Augusta Augusta, Georgia, United States, 30901 United States, Kentucky Baptist Hospital East Louisville, Kentucky, United States, 40207 Norton Cancer Institute Louisville, Kentucky, United States, 40207 United States, Louisiana Hematology Oncology Clinic, LLP Baton Rouge, Louisiana, United States, 70806 United States, Maryland Center for Cancer and Blood Disorders Bethesda, Maryland, United States, 20817 National Capital Clinical Research Consortium Bethesda, Maryland, United States, 20817 United States, Michigan Grand Rapids Clinical Oncology Program Grand Rapids, Michigan, United States, 49503 United States, Missouri Research Medical Center Kansas City, Missouri, United States, 64132 United States, Nebraska Nebraska Methodist Cancer Center Omaha, Nebraska, United States, 68114 United States, Ohio Oncology Hematology Care Cincinnati, Ohio, United States, 45242 United States, South Carolina South Carolina Oncology Associates, PA Columbia, South Carolina, United States, 29210 United States, Tennessee Chattanooga Oncology Hematology Associates Chattanooga, Tennessee, United States, 37404 Family Cancer Center Collierville, Tennessee, United States, 38017 Tennessee Oncology, PLLC Nashville, Tennessee, United States, 37023 United States, Virginia Peninsula Cancer Institute Newport News, Virginia, United States, 23601 Virginia Cancer Institute Richmond, Virginia, United States, 23235 Collapse << |
| NCT01076504 | - | - | Completed | - | - |
| NCT00388960 | Small Cell Lung Cancer | Phase 2 | Completed | - | Belgium ... more >> Algemeen Ziekenhuis Middelheim Antwerpen, Belgium, 2020 Universitair Ziekenhuis Antwerpen Edegem, Belgium, 2650 Universiteit Gent Gent, Belgium, 9000 U.Z. Gasthuisberg Leuven, Belgium, 3000 Domaine Universitaire du Sart-Tilman Liege, Belgium, 1BE Centre Hospitalier Regional de la Citadelle Liege, Belgium, 4000 Clinique Sainte Elisabeth Namur, Belgium, 5000 Italy Instituto Nazionale per la Ricerca sul Cancro Genova, Italy, 16132 Universita Degli Studi Di Udine Udine, Italy, 33100 Netherlands Academisch Medisch Centrum Amsterdam, Netherlands, 1105 AZ The Netherlands Cancer Institute Antoni Van Leeuwenhoekziekenhuis Amsterdam, Netherlands Medisch Spectrum Twente - Dept of Pulmonary Diseases Enschede, Netherlands, 7500 KA Leiden University Medical Centre Leiden, Netherlands, 2300RC Academisch Ziekenhuis Maastricht Maastricht, Netherlands, 6202 Isala Kliniek Zwolle, Netherlands, 8001 Poland Medical University of Gdansk - Dept Radiotherapy Gdansk, Poland, 80211 United Kingdom Clatterbridge Centre for Oncology NHS Trust Bebington, Merseyside, United Kingdom, CH684JY University of Dundee - Ninewells Hospital Dundee, Scotland, United Kingdom, D01 9SY Belfast City Hospital Belfast, United Kingdom, BT9 7AB Western General Hospital Edinburgh, United Kingdom, EH4 2XU Princess Royal Hospital Hull, United Kingdom, HU8 9HE Royal Marsden Hospital, London London, United Kingdom, SM2 5PT Christie Hospital Manchester, United Kingdom, M20 4BX Sir Bobby Robson Cancer Trials Research Centre Newcastle-Upon-Tyne, United Kingdom, NE4 6BE Royal Marsden Hospital Lung Unit Sutton, United Kingdom, (Surrey) SM2 5PT Collapse << |
| NCT00319969 | Small Cell Lung Cancer | Phase 2 | Completed | - | - |
| NCT00380835 | Metastatic Breast Cancer | Phase 2 | Withdrawn(Study Never Initiate... more >>d) Collapse << | - | United States, Connecticut ... more >> New Milford, Connecticut, United States, 06776 Sharon, Connecticut, United States, 06069 Torrington, Connecticut, United States, 06790 United States, Minnesota Burnsville, Minnesota, United States, 55337 Edina, Minnesota, United States, 55435-2150 Maplewood, Minnesota, United States, 55109 Minneapolis, Minnesota, United States, 55404 St. Paul, Minnesota, United States, 55102-2389 Woodbury, Minnesota, United States, 55125 United States, Missouri Columbia, Missouri, United States, 65201 United States, New York Albany, New York, United States, 12208 Amsterdam, New York, United States, 12010 Hudson, New York, United States, 12534 Latham, New York, United States, 12110-0610 Rexford, New York, United States, 12148 Schenectady, New York, United States, 12308 Troy, New York, United States, 12180 United States, North Carolina Asheville, North Carolina, United States, 28803 United States, Texas Dallas, Texas, United States, 75230-2510 Dallas, Texas, United States, 75231-4400 Dallas, Texas, United States, 75246 El Paso, Texas, United States, 79902 El Paso, Texas, United States, 79915 Houston, Texas, United States, 77024 Midland, Texas, United States, 79701-5946 Odessa, Texas, United States, 79761 Plano, Texas, United States, 75075-7787 Tyler, Texas, United States, 75702 Collapse << |
| NCT00660504 | Lung Cancer | Phase 3 | Completed | - | China, Fujian ... more >> Fuzhou, Fujian, China China, Gansu Lanzhou, Gansu, China China, Guangdong Guangzhou, Guangdong, China China, Hunan Changsha, Hunan, China China, Jiangsu Nanjing, Jiangsu, China China, Jiangxi Nanchang, Jiangxi, China China, Jilin Changchun, Jilin, China China, Liaoning Dalian/Shenyang, Liaoning, China Shenyang, Liaoning, China China, Shanxi Xian, Shanxi, China China, Sichuan Chengdu, Sichuan, China China, Zhejiang Hangzhou, Zhejiang, China China Beijing, China Shanghai, China Tianjin, China Collapse << |
| NCT01355705 | Multiple Myeloma | Phase 1 Phase 2 | Completed | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
| NCT00660504 | - | - | Completed | - | - |
| NCT01904253 | Small Cell Lung Cancer (SCLC) | Phase 2 | Terminated(The preliminary dat... more >>a does not suggest any safety signal, but an ad hoc interim analysis showed an imbalance of PFS between the two arms) Collapse << | - | Germany ... more >> Klinikum Mannheim GmbH Universitaetsklinikum Mannheim, Baden-Württemberg, Germany Lungenklinik Heckeshorn- HELIOS Kliniken GmbH Berlin, Germany LungenClinic Grosshansdorf Grosshansdorf, Germany Klinikum Koeln-Merheim Koplin, Germany St. Hildegardis-Krankenhaus- Katholisches Klinikum Mainz Mainz, Germany LMU-Campus Innenstadt Muenchen, Germany Italy Azienda Ospedaliero-Universitaria S. Luigi Gonzaga Orbassano, Turin, Italy IRCCS Centro di Riferimento Oncologico di Aviano, Divisione Oncologia Medica A Aviano, Italy Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari Bari, Italy Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico Catania, Italy Azienda Ospedaliera Instituti Ospitalieri di Cremona Cremona, Italy Azienda Ospedaliera Universitaria Careggi Firenze, Italy IEO Istituto Europeo di Oncologia Milano, Italy Azienda Ospedaliera San Gerardo U.O Oncologia Medica Monza, Italy Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia Reggio Emilia, Italy A.O.V.V. Ospedale Eugenio Morelli-Sondalo Sondalo, Italy Japan National Cancer Center Hospital East Chiba, Japan, 277-8577 National Kyushi Cancer Center Fukuoka, Japan, 811-1395 Hyogo Cancer Center Hyogo, Japan, 673-8588 Saitama Cancer Center Saitama, Japan, 362-0806 Shizuoka Cancer Center Shizuoka, Japan, 411-8777 Nippon Medical School Hospital Tokyo, Japan, 113-8603 Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo, Japan, 135-8550 Collapse << |
| NCT01259375 | Soft Tissue Sarcoma | Phase 2 | Completed | - | United States, California ... more >> Santa Monica Santa Monica, California, United States, 90403 United States, Utah Huntsman Cancer Institute Salt Lake City, Utah, United States, 84112 Collapse << |
| NCT01355705 | - | - | Completed | - | - |
| NCT00547651 | Small Cell Lung Cancer | Phase 3 | Completed | - | - |
| NCT00375193 | Small Cell Lung Cancer | Phase 2 | Completed | - | - |
| NCT00890955 | Lung Cancer | Phase 1 | Completed | - | United States, Arkansas ... more >> Highlands Oncology Group Springdale, Arkansas, United States, 72764 United States, Delaware Helen F. Graham Cancer Center Newark, Delaware, United States, 19713 United States, Illinois Medical & Surgical Specialists, LLC Galesburg, Illinois, United States, 61401 United States, Indiana Cancer Care Center of Southern Indiana Bloomington, Indiana, United States, 47403 Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 Medical Consultants, P.C. Muncie, Indiana, United States, 47303 Northern Indiana Cancer Research Consortium South Bend, Indiana, United States, 46601 United States, Missouri Siteman Cancer Center St. Louis, Missouri, United States, 63110 United States, Oregon Providence Portland Medical Center Portland, Oregon, United States, 97213 United States, Pennsylvania Fox Chase Cancer Center Extramural Research Program Rockledge, Pennsylvania, United States, 19046 Collapse << |
| NCT01259375 | - | - | Completed | - | - |
| NCT01331824 | - | - | Terminated(due to a developmen... more >>t decision by the funder) Collapse << | - | - |
| NCT00915083 | Advanced Solid Tumors | Phase 1 | Completed | - | United States, California ... more >> University of California San Diego La Jolla, California, United States, 92093 Sarcoma Oncology Center Santa Monica, California, United States, 90403 United States, Indiana Indiana University Cancer Pavilion Indianapolis, Indiana, United States, 46202 United States, Kentucky James Graham Brown Cancer Center Louisville, Kentucky, United States, 40202 United States, Maryland Sinai Hospital of Baltimore- Alvin and Lois Lapidus Cancer Institute Baltimore, Maryland, United States, 21215 United States, New York Montefiore Medical Center Bronx, New York, United States, 10467 United States, Texas UT Health Science Center at San Antonio- Cancer Therapy and Research Center San Antonio, Texas, United States, 78229 United States, Utah Hunstman Cancer Institute Salt Lake City, Utah, United States, 84112 Collapse << |
| NCT01364727 | - | - | Active, not recruiting | - | - |
| NCT01331824 | Bladder Cancer | Phase 2 | Terminated(due to a developmen... more >>t decision by the funder) Collapse << | - | United States, Arizona ... more >> Banner MD Anderson Cancer Center Gilbert, Arizona, United States, 85234 United States, Indiana Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, New York Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Collapse << |
| NCT01364727 | Thymoma Thymu... more >>s Cancer Thymic Carcinoma Collapse << | Phase 2 | Active, not recruiting | December 2018 | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 United States, Indiana Indiana University Indianapolis, Indiana, United States, 46202 Collapse << |
| NCT01033032 | Metastatic Breast Cancer | Phase 1 Phase 2 | Completed | - | United States, Arkansas ... more >> NEA Baptist Clinic Jonesboro, Arkansas, United States, 72401 United States, Florida Florida Cancer Specialists Fort Myers, Florida, United States, 33901 United States, Georgia Northeast Georgia Medical Center Gainesville, Georgia, United States, 30501 United States, Kentucky Baptist Hospital East Louisville, Kentucky, United States, 40207 Norton Cancer Institute Louisville, Kentucky, United States, 40207 United States, Louisiana Hematology Oncology Clinic, LLP Baton Rouge, Louisiana, United States, 70809 United States, Maryland Center for Cancer and Blood Disorders Bethesda, Maryland, United States, 20817 National Capital Clinical Research Consortium Bethesda, Maryland, United States, 20817 United States, Michigan Grand Rapids Clinical Oncology Program Grand Rapids, Michigan, United States, 49503 United States, Nebraska Nebraska Methodist Cancer Center Omaha, Nebraska, United States, 68114 United States, New Hampshire Portsmouth Regional Hospital Portsmouth, New Hampshire, United States, 03801 United States, Ohio Oncology Hematology Care, Inc Cincinnati, Ohio, United States, 45242 United States, Pennsylvania Berks Hematology Oncology Associates West Reading, Pennsylvania, United States, 19611 United States, Tennessee Tennessee Oncology, PLLC Nashville, Tennessee, United States, 37203 United States, Texas The Center for Cancer and Blood Disorders Fort Worth, Texas, United States, 76104 United States, Virginia Peninsula Cancer Institute Newport News, Virginia, United States, 23601 Collapse << |
| NCT01033032 | - | - | Completed | - | - |
