|(4-(4-氨基-6,7-二甲氧基喹唑啉-2-基)哌嗪-1-基)(四氢呋喃-2-基)甲酮盐酸盐二水合物|CsnPharm

CAS No.: 70024-40-7

盐酸特拉唑嗪(二水合物) Catalog No. CSN12052

Synonyms: Terazosin;Terazosin hydrochloride;Hytrin

Terazosin HCl is an α-adrenergic (AL-fa ad-ren-ER-jik) blocker used in the therapy of hypertension and benign prostatic hypertrophy with climination half-life‎ of ‎12 hours.

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描述Terazosin Hydrochloride Dihydrate is a α1-adrenoceptor blocker with a long lasting actionused for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH)^[3].Terazosin therapy results in a significant reduction in blood pressure in patients with mild to moderate essential hypertension, with little influence on heart rate^[4]. Terazosin alleviated organ damage and improved survival in rodent models of stroke and sepsis^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00000620	Atherosclerosis ... more >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease Collapse <<	Phase 3	Completed	-	United States, Minnesota ... more >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada Collapse <<
NCT01323998	-	-	Completed	-	-
NCT03339258	Stress Disorders, Post-Traumat... more >>ic Collapse <<	Phase 2	Recruiting	June 2021	United States, California ... more >> San Francisco VA Medical Center Recruiting San Francisco, California, United States, 94121 Contact: Andrew Levihn-Coon, B.A. 415-221-4810 ext 23809 andrew.levihn-coon@va.gov Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1743 mL
- 10.8714 mL
- 21.7427 mL
- 5 mM
- 0.4349 mL
- 2.1743 mL
- 4.3485 mL
- 10 mM
- 0.2174 mL
- 1.0871 mL
- 2.1743 mL

技术信息

CAS号

70024-40-7

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H30ClN5O6

运输

蓝冰

分子量

459.92

别名

Terazosin;Terazosin hydrochloride;Hytrin;A-45975;Terazosin HCl hydrate;Terazosin HCl dihydrate;盐酸特拉唑嗪(二水合物

溶解度

DMSO	24.0 mg/mL (52.2 mM)
Water	Insoluble
Ethanol	Insoluble

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00000620	Atherosclerosis ... more >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease Collapse <<	Phase 3	Completed	-	United States, Minnesota ... more >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada Collapse <<
NCT01323998	-	-	Completed	-	-
NCT03339258	Stress Disorders, Post-Traumat... more >>ic Collapse <<	Phase 2	Recruiting	June 2021	United States, California ... more >> San Francisco VA Medical Center Recruiting San Francisco, California, United States, 94121 Contact: Andrew Levihn-Coon, B.A. 415-221-4810 ext 23809 andrew.levihn-coon@va.gov Collapse <<
NCT01323998	-	-	Completed	-	-
NCT01332487	-	-	Completed	-	-
NCT01332435	-	-	Completed	-	-
NCT01332487	-	-	Completed	-	-
NCT00000620	-	-	Completed	-	-
NCT03653845	Primary Aldosteronism ... more >> Hypertension Collapse <<	Phase 3	Recruiting	January 1, 2020	China, Chongqing ... more >> The third hospital affiliated to the Third Military Medical University Recruiting Chongqing, Chongqing, China, 400042 Contact: Hongbo He, MD. 86-23-68757880 cqhehongbo@gmail.com Principal Investigator: Zhiming Zhu, MD. China The third hospital affiliated to the Third Military Medical University Recruiting Chongqing, China, 400042 Contact: Zhiming Zhu, MD, PhD 86-023-68705094 zhuzm@yahoo.com Principal Investigator: Zhiming Zhu, MD, PhD Collapse <<
NCT00684489	Hypertension	Not Applicable	Completed	-	-
NCT01386983	-	-	Completed	-	-
NCT01386983	-	-	Completed	-	-
NCT01390870	-	-	Completed	-	-
NCT01332435	-	-	Completed	-	-
NCT01390870	-	-	Completed	-	-
NCT02966717	Renal Insufficiency, Chronic ... more >> Nephrotic Syndrome Collapse <<	Phase 2	Active, not recruiting	October 2021	China, Guangdong ... more >> Zhujiang Hospital, Southern Medical University Guangzhou, Guangdong, China, 510282 Collapse <<
NCT01435954	-	-	Completed	-	-
NCT00438113	Atrial Fibrillation	Phase 4	Completed	-	Canada, Nova Scotia ... more >> QE II Health Sciences Centre Halifax, Nova Scotia, Canada, B3H 3A7 Collapse <<
NCT00687388	Benign Prostatic Hyperplasia	Phase 4	Withdrawn(in order to prepare ... more >>a new clinical trial to evaluate with pathological change) Collapse <<	-	Korea, Republic of ... more >> Severance Hospital Seoul, Korea, Republic of, 120-752 Samsung Medical Center Seoul, Korea, Republic of, 135-710 Asan Medical Center Seoul, Korea, Republic of, 138-736 Collapse <<
NCT02244333	-	-	Completed	-	-
NCT02046395	Type 2 Diabetes ... more >> Hypertension Collapse <<	Phase 4	Recruiting	December 2019	United States, Louisiana ... more >> Tulane University Health Sciences Center Recruiting New Orleans, Louisiana, United States, 70112 Contact: Bonnie L Katalenich, MPH 504-988-0200 bkatalen@tulane.edu Principal Investigator: Tina Thethi, MD, MPH Collapse <<
NCT01530243	Disorder of Urinary Stent	Phase 2 Phase 3	Completed	-	Iran, Islamic Republic of ... more >> Imam Khomeini Hospital Urmia, Azerbaijan-gharbi, Iran, Islamic Republic of Collapse <<
NCT01530243	-	-	Completed	-	-
NCT01218243	-	-	Completed	-	-
NCT00693199	Lower Urinary Tract Symptoms ... more >> Hypertension Collapse <<	Not Applicable	Completed	-	China, Anhui ... more >> Biomedicine Inistitute of Anhui Medical University Hefei, Anhui, China, 230032 Collapse <<
NCT00563485	Prostatic Hyperplasia ... more >> Urinary Retention Collapse <<	Not Applicable	Terminated	-	China ... more >> Prince of Wales Hospital Hong Kong, China Collapse <<
NCT01366664	Ejaculation	Phase 1	Completed	-	United States, Alabama ... more >> Anniston, Alabama, United States United States, Arizona Tempe, Arizona, United States United States, California Costa Mesa, California, United States United States, Florida Miramar, Florida, United States United States, Tennessee Knoxville, Tennessee, United States United States, Texas Dallas, Texas, United States Collapse <<
NCT02244255	Prostatic Hyperplasia	Phase 4	Completed	-	-
NCT01508637	Cardiovascular Effects	Not Applicable	Unknown	December 2015	United States, Washington ... more >> University of Washington Medical Center Recruiting Seattle, Washington, United States, 98195 Collapse <<
NCT03195673	Carotid Artery Stenosis	Phase 2	Recruiting	December 15, 2019	China, Beijing ... more >> Beijing Anzhen Hospital Recruiting Beijing, Beijing, China, 100029 Contact: He Yin, MD The Luhe Teaching Hospital of the Capital Medical University Recruiting Beijing, Beijing, China, 101100 Contact: Xiaokun Geng, MD Collapse <<
NCT00449683	Hyperhidrosis	Phase 4	Completed	-	United States, Pennsylvania ... more >> Thomas Jefferson University, Department of Psychiatry Philadelphia, Pennsylvania, United States, 19107 Collapse <<
NCT01218243	Benign Prostatic Hyperplasia (... more >>BPH) Collapse <<	Phase 2	Completed	-	China ... more >> Guang'an Men Hospotal Affiliated to China Academy of Chinese Medical Sciences Beijing, China, 100053 Collapse <<
NCT00237510	Antidepressant Induced Excessi... more >>ve Sweating Collapse <<	Not Applicable	Completed	-	United States, Pennsylvania ... more >> Thomas Jefferson University Department of Psychiatry and Human Behavior Philadelphia, Pennsylvania, United States, 19107 Collapse <<
NCT00700583	Nocturia	Not Applicable	Completed	-	Korea, Republic of ... more >> Department of Urology, Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Collapse <<

盐酸特拉唑嗪(二水合物) Catalog No. CSN12052

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