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CAS No.: 4871-97-0

莪术醇 Catalog No. CSN16370

Synonyms: (-)-Curcumol;莪术醇

Curcumol is a sesquiterpene originally isolated from curcuma rhizomes showing anticancer activities both in vitro and in vivo.

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400-920-2911

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技术信息

生物活性

描述Curcumol, a pharmacologically active sesquiterpenoid, which is an imperative bioactive constituent of several plants mainly from genus Curcuma. Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers^[3]. Curcumol reduced the proliferation of CRC (colorectal cancer) cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment^[4]. Furthermore, curcumol evidently reduced cell proliferation and facilitated cell apoptosis in BGC-823/DDP and BGC-823 cells. Curcumol suppressed the PI3K/AKT pathway dose-dependently in BGC-823/DDP and BGC-823 cells^[5]. Curcumol inhibits the expression of PD-L1 (programmed cell death-ligand 1) through crosstalk between HIF-1α and p-STAT3 (T705) signaling pathways in hepatic cancer^[6]. Curcumol attenuated melanoma progression and concomitantly suppressed ERK/NF-κB signaling and promoted miR-152-3p expression to inactivate the c-MET/PI3K/AKT signaling pathway^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00475683	Chemotherapy Induced Mucositis	Phase 3	Completed	-	Israel ... more >> Hadassah Medical Organization Jerusalem, Israel Collapse <<
NCT00542711	Healthy	Phase 1	Withdrawn(Technical difficulti... more >>es) Collapse <<	-	Israel ... more >> Hadassah Medical Organization Jerusalem, Israel Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.2310 mL
- 21.1551 mL
- 42.3102 mL
- 5 mM
- 0.8462 mL
- 4.2310 mL
- 8.4620 mL
- 10 mM
- 0.4231 mL
- 2.1155 mL
- 4.2310 mL

技术信息

CAS号

4871-97-0

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H24O2

运输

蓝冰

分子量

236.35

别名

(-)-Curcumol;莪术醇

溶解度

DMSO	47.0 mg/mL (198.9 mM)
Water	Insoluble
Ethanol	45.0 mg/mL (190.4 mM)

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