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CAS No.: 138-52-3

水杨苷 Catalog No. CSN13702

Synonyms: 水杨苷;D-(−)-Salicin;Salicoside

Salicin is a non-selective COX-1 and COX-2 inhibitor, it is a phenol β-glycosid isolated and purified from the peel of Salix alba L.and shows anti-inflammatory effects.

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技术信息

生物活性

描述Salicin is a natural COX inhibitor. At the cellular level, salicin attenuates IL-1β-induced mitochondrial injury as revealed by its preservation on mitochondrial membrane potential (MMP). Furthermore, salicin inhibits IL-1β-induced production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1) ^[3]. Salicin significantly reduced cell viability, cytokines, and matrix metalloproteinases-1/-3 expression in IL-1β-induced RA-FLSs and inhibited ROS generation and p65 phosphorylation as compared with IL-1β-induced treatment. Moreover, salicin promoted Nrf2 nuclear translocation and HO-1 expression and reduced ROS production in IL-1β-induced RA-FLSs^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01920841	Weight Loss	Not Applicable	Withdrawn(Study Design changed... more >> and will be resubmitted as a new study) Collapse <<	-	United States, Louisiana ... more >> Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 Collapse <<
NCT01956500	Joint Pain, Stiffness, Functio... more >>n Collapse <<	Not Applicable	Completed	-	United States, North Carolina ... more >> ASU Human Performance Laboratory, North Carolina Research Campus Kannapolis, North Carolina, United States, 28081 Collapse <<

参考文献

[1] Akao T, Yoshino T, et al. Evaluation of salicin as an antipyretic prodrug that does not cause gastric injury. Planta Med. 2002 Aug;68(8):714-8.
[2] Maclagan T. The Treatment of Rheumatism by Salicin and Salicylic Acid. Br Med J. 1876 May 20;1(803):627.
[3] Song Y, Tian X, Wang X, Feng H. Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells. Artif Cells Nanomed Biotechnol. 2019;47(1):1995-2002
[4] Zhai KF, Duan H, Khan GJ, et al. Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways. J Agric Food Chem. 2018;66(24):6073-6082

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4931 mL
- 17.4656 mL
- 34.9311 mL
- 5 mM
- 0.6986 mL
- 3.4931 mL
- 6.9862 mL
- 10 mM
- 0.3493 mL
- 1.7466 mL
- 3.4931 mL

技术信息

CAS号

138-52-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H18O7

运输

蓝冰

分子量

286.28

别名

水杨苷;D-(−)-Salicin;Salicoside

溶解度

DMSO	56.0 mg/mL (195.6 mM)
Water	22.0 mg/mL (76.8 mM)
Ethanol	Insoluble

动物实验配方

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