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CAS No.: 58-61-7

腺嘌呤核苷 Catalog No. CSN23524

Synonyms: 腺苷;Adenine riboside;D-Adenosine

Adenosine is a nucleoside that is composed of adenine and d-ribose and plays many important biological roles in addition to being components of DNA and RNA.

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技术信息

生物活性

描述Adenosine, a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation^[1]. Adenosine is formed by enzymatic degradation of adenosine triphosphate and eliminated by phosphorylation to adenosine monophosphate or by deamination to inosine. Extracellular adenosine as a signaling molecule binds to adenosine receptors, which may trigger via their cognate trimeric G proteins different signaling pathways^[2]. As the core molecule of adenosine triphosphate (ATP), adenosine exists in equilibrium with the adenine nucleotide pool and contributes to cellular energy charge, a quantification of relative amounts of available ATP, ADP, AMP and adenosine. Beyond participating in overall energy balance and thus in maintaining cellular homeostasis, adenosine critically influences dynamic signaling in the nervous system. In particular, adenosine has an effect on and is affected by excitatory synaptic transmission^[3]. Adenosine is a common metabolite of ATP, which exhibits cytotoxic effects at high concentrations. Adenosine (1.0-4.0 mM; 12-24 hours) inhibits cell viability and triggers ER stress in HepG2 cells. Adenosine (2.0 mM; 12-24 hours) induces autophagy in HepG2 cells ^[4].
参考文献

[1] Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007 Jul;14(7):1315-23
[2] Novotný J. Adenosin a jeho role ve fyziologii [Adenosine and its role in physiology]. Cesk Fysiol. 2015;64(1):35-44. Slovak
[3] Masino SA, Dulla CG. Adenosine, glutamate and pH: interactions and implications. Neurol Res. 2005 Mar;27(2):149-52
[4] Zhou XT, Pu ZJ, Liu LX, Li GP, Feng JL, Zhu HC, Wu LF. Inhibition of autophagy enhances adenosine‑induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019 Feb;41(2):829-838

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7419 mL
- 18.7097 mL
- 37.4194 mL
- 5 mM
- 0.7484 mL
- 3.7419 mL
- 7.4839 mL
- 10 mM
- 0.3742 mL
- 1.8710 mL
- 3.7419 mL

技术信息

CAS号

58-61-7

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H13N5O4

运输

蓝冰

分子量

267.24

别名

腺苷;Adenine riboside;D-Adenosine

溶解度

DMSO	12.0 mg/mL (44.9 mM)
Water	Insoluble
Ethanol	Insoluble

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