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CAS No.: 480-18-2

花旗松素 Catalog No. CSN16850

Synonyms: 二氢槲皮素;(+)-Dihydroquercetin;(+)-Taxifolin

Taxifolin is an inhibitor of VEGFR-2 kinase and collagenase (IC50 = 193.3 μM) and it can be found in many plants such as taxus chinensis, siberian larch, cedrus deodara and so on.

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技术信息

生物活性

描述Taxifolin has an important anti tyrosinase activity. Taxifolin effectively inhibited collagenase, IC50 was 193.3 μ M^[3]. The apparent permeability of taxifolin across Caco-2 cell monolayersa (widely used in vitro model of the human small intestinal mucosa) was shown to be less than 1 × 10−6 cm/s, and the absolute bioavailability of taxifolin was reported as 0.17% in rats. Moreover, the urinary excretion of taxifolin was found to be only 0.24% of the dosage^[4].
参考文献

[1] Yang P, Xu F, et al.Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209.
[2] Lee SB, Cha KH, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9.
[3] Angelis A, Hubert J, Aligiannis N, Michalea R, Abedini A, Nuzillard JM, Gangloff SC, Skaltsounis AL, Renault JH. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11):1586. doi: 10.3390/molecules21111586. PMID: 27879645; PMCID: PMC6272914.
[4] Yang P, Xu F, Li HF, Wang Y, Li FC, Shang MY, Liu GX, Wang X, Cai SQ. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9):1209. doi: 10.3390/molecules21091209. PMID: 27649117; PMCID: PMC6273498.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2868 mL
- 16.4338 mL
- 32.8675 mL
- 5 mM
- 0.6574 mL
- 3.2868 mL
- 6.5735 mL
- 10 mM
- 0.3287 mL
- 1.6434 mL
- 3.2868 mL

技术信息

CAS号

480-18-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H12O7

运输

蓝冰

分子量

304.25

别名

二氢槲皮素;(+)-Dihydroquercetin;(+)-Taxifolin

溶解度

DMSO	59.0 mg/mL (193.9 mM)
Water	Insoluble
Ethanol	59.0 mg/mL (193.9 mM)

动物实验配方

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