|(1S,2S,3R,4R)-3-((S)-1-乙酰氨基-2-乙基丁基)-4-胍基-2-羟基环戊烷羧酸三水合物|CsnPharm

CAS No.: 1041434-82-5

Synonyms: RWJ 270201 trihydrate;BCX 1812 trihydrate;BCX-1812

Peramivir Trihydrate is a novel cyclopentane neuraminidase inhibitor of influenza virus, used to treat acute symptomatic influenza A and B.

规格	价格	促销价格	库存	数量

400-920-2911

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生物活性

靶点 Neuraminidase

IC50:0.09nM
描述Peramivir trihydrate (RWJ-270201, BCX-1812) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes. RWJ-270201 has efficacy comparable to or better than earlier NA inhibitors against a wide range of influenza A and B isolates, including recently emerged and avian strains, both in vitro and in a lethal murine model of influenza^[3]. Peramivir is effective against a variety of influenza A and B subtypes and has a lower half-maximal inhibitory concentration compared to other NAIs in in vitro studies. The long half-life of peramivir allows for once-daily dosing. The drug is eliminated primarily by the kidneys, warranting dose adjustments in patients with renal dysfunction^[4]. Peramivir is administered as a single-dose via the intravenous route providing a valuable therapeutic alternative for critically ill patients or those unable to tolerate other administration routes^[5].
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CAS号	1041434-82-5	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H34N4O7	运输	蓝冰
分子量	382.45	别名	RWJ 270201 trihydrate;BCX 1812 trihydrate;BCX-1812;S021812;帕拉米韦三水合物

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