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CAS No.: 77-52-1

熊果酸 Catalog No. CSN19453

Synonyms: 熊果酸;Prunol;Urson

Ursolic acid is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

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技术信息

生物活性

描述Ursolic Acid is a pentacyclic triterpene acid abundantly distributed in most of fruits and vegetables. Free radical scavenging activities of ursolic acid were evaluated by hydroxyl radical assay, superoxide anion assay, and nitric oxide assay, and IC50 values of ursolic acid for each were 51.83±4.16, 42.07±3.14, and 34.60±3.16 μg/mL, respectively^[3]. Intraperitoneal treatment (25 mg /mL) with Ursolic Acid was responsible for the maintenance of muscle mass and the increased diameter of muscle fibres via increased IGF‐1 secretion^[4]. Moreover,Ursolic Acid significantly inhibited cell proliferation and cell apoptosis, and decreased DNA damage in UVB-radiated lymphocytes^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03216876	Primary Sclerosing Cholangitis	Phase 1	Withdrawn(Lack of feasibility)	July 2019	United States, California ... more >> Univeristy of California Davis Medical Center Sacramento, California, United States, 95817 Collapse <<
NCT02401113	Sarcopenia	Phase 2 Phase 3	Completed	-	-
NCT02337933	Metabolic Syndrome X	Phase 2	Completed	-	Mexico ... more >> Instituto de Terapéutica Experimental y Clínica Guadalajara, Jalisco, Mexico, 44140 Collapse <<

参考文献

[1] Wozniak l, Skąpska S, Marszalek K. Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities. Molecules. 2015 Nov 19;20(11):20614-41.
[2] Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol. 1995 Dec 1;49(2):57-68.
[3] Yin R, Li T, Tian JX, Xi P, Liu RH. Ursolic acid, a potential anticancer compound for breast cancer therapy. Crit Rev Food Sci Nutr. 2018 Mar 4;58(4):568-574. doi: 10.1080/10408398.2016.1203755. Epub 2017 Oct 4. PMID: 27469428.
[4] Katashima CK, Silva VR, Gomes TL, Pichard C, Pimentel GD. Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review. Obes Rev. 2017 Jun;18(6):700-711. doi: 10.1111/obr.12523. Epub 2017 Mar 23. PMID: 28335087.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1896 mL
- 10.9481 mL
- 21.8962 mL
- 5 mM
- 0.4379 mL
- 2.1896 mL
- 4.3792 mL
- 10 mM
- 0.2190 mL
- 1.0948 mL
- 2.1896 mL

技术信息

CAS号

77-52-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H48O3

运输

蓝冰

分子量

456.70

别名

熊果酸;Prunol;Urson;Malol

溶解度

DMSO	30.0 mg/mL (65.7 mM) warming
Water	Insoluble

动物实验配方

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