|3-吲哚甲醇|CsnPharm

CAS No.: 700-06-1

3-吲哚甲醇 Catalog No. CSN10458

Synonyms: 3-吲哚甲醇;I3C;3-Indolemethanol

Indole-3-Carbinol is a naturally occuring plant hormone found in cruciferous vegetables, which can both inhibit carcinogenesis in several animal species and enhance tumor incidence if administered at a post-initiation stage.

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技术信息

生物活性

描述Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). I3C inhibits the proliferation of THP-1 cells in a dose- and time-dependent manner with minimal toxicity over normal monocytes. I3C could exert its antileukemic effects through AhR activation which is associated with programed cell death and G1 cell cycle arrest in a dose- and time-dependent manner^[3]. Treatment with I3C led to repressed colonic inflammation and prevention of microbial dysbiosis caused by colitis, increasing a subset of gram-positive bacteria known to produce butyrate. I3C attenuates colitis primarily through induction of IL-22, which leads to modulation of gut microbiota that promote antiinflammatory butyrate^[4]. I3C prevented EtOH (ethanol) -induced liver injury via attenuating the damaging effect of ethanol on the gut-liver-adipose tissue axis^[5]. I3C may induce apoptosis in human osteosarcoma MG-63 and U2OS cells via the activation of apoptotic signaling pathways by FOXO3^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00910884	-	-	Not yet recruiting	February 2020	United States, Washington ... more >> Brabant Research, Incorporated Not yet recruiting Spokane Valley, Washington, United States, 99216 Contact: Richard E. Lasker, PhD 509-340-9902 rel@brabantresearch.com Collapse <<
NCT02483624	SLE	Phase 1	Terminated	-	-
NCT02525159	Breast Cancer	Phase 3	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.7947 mL
- 33.9734 mL
- 67.9468 mL
- 5 mM
- 1.3589 mL
- 6.7947 mL
- 13.5894 mL
- 10 mM
- 0.6795 mL
- 3.3973 mL
- 6.7947 mL

技术信息

CAS号

700-06-1

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H9NO

运输

蓝冰

分子量

147.17

别名

3-吲哚甲醇;I3C;3-Indolemethanol;吲哚-3-甲醇

溶解度

DMSO	29.0 mg/mL (197.0 mM)
Ethanol	29.0 mg/mL (197.0 mM)

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00910884	-	-	Not yet recruiting	February 2020	United States, Washington ... more >> Brabant Research, Incorporated Not yet recruiting Spokane Valley, Washington, United States, 99216 Contact: Richard E. Lasker, PhD 509-340-9902 rel@brabantresearch.com Collapse <<
NCT02483624	SLE	Phase 1	Terminated	-	-
NCT02525159	Breast Cancer	Phase 3	Completed	-	-
NCT00100958	Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse <<	Phase 1	Completed	-	United States, Kansas ... more >> Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Kansas City, Kansas, United States, 66160-7357 Collapse <<
NCT01344330	-	-	Unknown	April 2017	United States, Oregon ... more >> Oregon Health & Science University Recruiting Portland, Oregon, United States, 97201 Contact: Matthew French 503-494-7004 frenchm@ohsu.edu Contact: Carrie Farrar 503-494-4233 farrarc@ohsu.edu Principal Investigator: David Lieberman, MD Collapse <<
NCT00033345	Breast Cancer	Phase 1	Completed	-	United States, Kansas ... more >> University of Kansas Medical Center Kansas City, Kansas, United States, 66160-7320 Collapse <<
NCT00988845	Obesity	Phase 2	Terminated(Slow accrual in the... more >> high BMI group) Collapse <<	-	United States, Wisconsin ... more >> University of Wisconsin Madison, Wisconsin, United States, 53792 Collapse <<
NCT03687073	Smoking	Phase 1	Recruiting	July 2019	United States, Minnesota ... more >> Masonic Cancer Center at University of Minnesota Recruiting Minneapolis, Minnesota, United States, 55455 Contact: Hanna Vanderloo, RN, MSN Collapse <<
NCT00579332	Biochemical Failure	Phase 2 Phase 3	Completed	-	United States, Tennessee ... more >> Vanderbilt_University Nashville, Tennessee, United States, 23233 Collapse <<
NCT00607932	Prostate Cancer	Not Applicable	Completed	-	-

3-吲哚甲醇 Catalog No. CSN10458

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