CAS No.: 87402-88-8
(-)-Denudatin B Catalog No. CSN14635
Synonyms: Denudatin B
Denudatin B, a natural product isolated and purified from the herbs of Kadsura coccinea, inhibits the aggregation and ATP release of washed rabbit platelets caused by platelet-activating factor (PAF) in a concentration-dependent manner, has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, relaxes vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels and its effect to increase cGMP may enhance the vasorelaxation and shows potent 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activity.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Yu SM, Chen CC, et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990 Oct 2;187(1):39-47.
- [2] Teng CM, Yu SM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990 Jul 1;59(1):121-30.
实验方案
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- 储存液制备
技术信息
| CAS号 | 87402-88-8 | 储存条件 |
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| 分子式 | C21H24O5 | 运输 | 蓝冰 | |
| 分子量 | 356.41 | 别名 | Denudatin B |
