|Verminoside, a natural product isolated and purified from the barks of Kigelia pinnata with anti-inflammatory effect, inhibits both iNOS expression and NO release in the LPS-induced J774.A1 macrophage cell line.
|Tropolone inhibits both mono-and o-dihydroxyphenolase activity of mushroom tyrosinase.
|Tricin, a natural product isolated and purified from the herb of Avena sativa, is evaluated as a type of tyrosinase inhibitor, exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade, may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis, and is with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication.
|Sweroside, a natural product isolated and purified from the herbs of Swertia bimaculata with strong hepatoprotective, anti-osteoporotic, insulin-mimicking, and wound-healing effects, can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells.
|Steppogenin is a natural prodcut isolated and purified from the stems of Cudrania tricuspidata with cytotoxicity and significant tyrosinase inhibition activity.
|Soyacerebroside I is a natural product isolated and purified from the fruits of Glycine max with a potent tyrosinase inhibitory activity and anti-inflammatory activity.
|Pedalitin is a natural mixed-type inhibitor of tyrosinase isolated and purified from the herbs of Rabdosia rubescens, and is also a competitive inhibitor of α-glucosidase.
|Oxyresveratrol is a naturallly occuring stilbenoid found in the heartwood of Artocarpus lakoocha, which works as a potent tyrosinase inhibitor and also possesses anti-proliferative, anti-inflammatory, and cardioprotective properties.
|Methyl cinnamate is the methyl ester of cinnamic acid found naturally in a variety of plants. It could be used in the flavor and perfume industries.
|Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research.
|Gnetol is a tyrosinase inhibitor isolated from genus Gnetum.
|Glycolic acid (or hydroxyacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel.
|Glabrene, a natural product isolated and purified from the roots of Glycyrrhiza uralensis with estrogen-like activity, can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC), exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that it may serve as candidates for skin-lightening agents.
|Fumaric acid a reversible inhibitor of tyrosinase.
|Deoxyarbutin is a reversible inhibitor of tyrosinase with IC50 of 50 nM.
|Dalbergioidin, a natural product isolated and purified from the roots of Parochetus communis with tyrosinase inhibitory activity with an IC50 of 20 mM, shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism, protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, and ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway.
|beta-Hydroxypropiovanillone is a natural product isolated and purified from the barks of Pinus yunnanensis showing potent tyrosinase inhibitory activity.
|Benzylacetone is an aromatic compound from agarwood. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity， with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively. Benzylacetone has appetite-enhancing and locomotor-reducing effects.
|Arbutin is an inhibitor of tyrosinase with IC50 of 1.09 mM and can prevent the formation of melanin. It is a glycosylated hydroquinone found in the leaves of arctostaphylos uvaursi.
|Aloin A, an anthracycline from aloe plants, can be used as a chemopreventive factor with antineoplastic activity. It exhibits inhibition of phosphodiesterase and tyrosinase.
|Aloesin (Aloeresin) is an active constituent of the herb aloe vera and displays anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin exerts its anticancer effect through the MAPK signaling pathway.
|4-Methoxysalicylaldehyde, a naturally occurring product, has a range of industrial applications in the preparation of organic compounds, drugs and therapeutic agents.
|4-Hexylbenzene-1,3-Diol is a mushroom tyrosinase inhibitor with local anaesthetic and antiseptic activities.
|4-Butylresorcinol, a phenol derivative, is an inhibit of tyrosinase with IC50 of 11.27 μM.
|4-(1-Phenylethyl)benzene-1,3-diol is a tyrosinase inhibitor.
|3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth.
|3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC50 of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant.
|2-Ketoglutaric acid, also known as alpha-ketoglutarate and AKG, is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle.
|Palmitoyl Tripeptide-5 TFA