Small Ubiquitin-like Modifier (or SUMO) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function.
|TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.
|ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays, which selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.
|Ginkgolic acid is a natural product isolated and purified from the leaves of Ginkgo biloba L.with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties.
|COH000 is an irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) with IC50 of 0.2 μM for SUMOylation in vitro.