|YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.
|Amifostine thiol 2HCl
|WR-1065 dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway and also exhibits broad spectrum antiviral activity in vitro.
|Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.
|Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
|Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.
|RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. It is MDM2-p53 interaction inhibitor and activates p53 expression.
|PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
|Plumbagin is an anticancer agent, induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation and inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice.
|PK11007 is mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53.
|PK11007 is a p53 targeting compond anti-tumor activities.
|Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
|Pifithrin-β is a potent p53 inhibitor with IC50 of 23 μM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
|Pifithrin-β hydrobromide is a potent p53 inhibitor with IC50 of 23 μM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
|Pifithrin-α hydrobromide is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
|p53 and MDM2 proteins-interaction-inhibitor racemate is an inhibitor of the interaction between p53 and MDM2 proteins.
|p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
|p53 and MDM2 proteins-interaction-inhibitor 2HCl is an inhibitor of the interaction between p53 and MDM2 proteins.
|NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) and showing no inhibition for p53 wild-type cells.
|NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.
|MI-773 is an orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity.
|Liriodenine, a natural product isolated and purified from the barks of Liriodendron chinense (Hemsl.) Sarg., with anti-fungal activity, inhibits progression of the CAOV-3 cell cycle in S phase and exhibits potent antitumor activities in laryngocarcinoma HEp-2 cells, in vitro and in vivo, via the upregulation of p53 expression.
|Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity.
|Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity.
|CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
|COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity.
|APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.
|Antitumor agent; suppresses mutant p53-bearing cancer cells
|AMG-232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction ((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).
|10-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., an antioxidant for human skin cell growth and a migration enhancer with potential to be a wound repair agent, has similar metabolic profiles to -shogaol and exhibit similar toxicity toward human colon cancer cells.
|(+)-Pinocembrin could inhibit p53 expression causing a lower Bax/Bcl-2 ratio and the release of cytochrome c that shows a neuroprotective effects. (+)-Pinocembrin can be extracted from the fruit of alpinia katsunadia hayata with antioxidant and anti-inflammatory antivities.