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p38 MAPK

p38 MAPK

货号 产品名 CAS号 信息
CSN16728 Neflamapimod 209410-46-8 VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
CSN16018 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide 745833-23-2 VX-702 is a highly selective inhibitor of p38α MAPK with IC50 of 4 -20 nM.
CSN21102 UM-164 903564-48-7 UM-164 is a potent dual c-Src/p38 kinase inhibitor that exhibits potent anti-TNBC activity in xenograft models. UM-164 inhibits p38 kinase and binds to an inactive c-Src conformation.
CSN26722 Talmapimod HCl 309915-12-6 Talmapimod, also known as SCIO-469, is an orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis.
CSN15958 TAK-715 303162-79-0 TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, being 28-fold selective for p38α over p38β, showing no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
CSN18029 TA-02 1784751-19-4 TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.
CSN13149 SKF-86002 72873-74-6 SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 μM and inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
CSN17172 Skepinone-L 1221485-83-1 Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
CSN26187 5-(((1R,3aR,4S,6aR)-4-(Benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan-1-yl)oxy)benzo[d][1,3]dioxole 526-07-8 Sesamolin is a furofuran lignan extracted from sesame seeds, which has beneficial physiological properties such as antioxidant, anti-mutagenic, anti-aging and anti-inflammatory activities. It was also found to inhibit lipid peroxidation in rat liver and kidney.
CSN27555 1H-indole-5-carboxamide 1670-87-7 SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation.
CSN18176 SD 0006 271576-80-8 SD-06 is a p38 MAP kinase inhibitor and inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83% inhibition at 1mg/kg, po).
CSN16503 7-Hydroxy-6-methoxy-2H-chromen-2-one 92-61-5 Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-κB and p38 MAPK.
CSN18198 Talmapimod 309913-83-5 SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38α in vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
CSN13746 SB 242235 193746-75-7 SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM.
CSN11899 SB 203580     152121-47-6 SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.
CSN18506 Adezmapimod HCl 869185-85-3 SB-203580 HCl is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.
CSN12267 SB 202190 152121-30-7 SB-202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also shows slightly weaker activity for BRD4 (Kd=3.4 μM).
CSN12897 SB 239063 193551-21-2 SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38α.
CSN16187 Saikosaponin A 20736-09-8 Saikosaponin A, a natural product isolated and purified from the root of Bupleurum chinense DC., with antioxidant activity, has an inhibitory activity against allergic asthma and an anti-inflammatory activity by inhibiting the MAPK and NF-κB pathways in LPS-stimulated RAW 264.7 cells, shows the most potent cytotoxicity against human cancer cells, and is an inhibitory for cell growth and DNA synthesis with 50-μg/mL.
CSN18788 R1487 HCl 449808-64-4 R1487 HCl is highly potent and highly selective inhibitors of p38α.
CSN13463 PH-797804 586379-66-0 PH-797804 is a pyridinone inhibitor of p38α with IC50 of 26 nM, being 4-fold selective versus p38β and does not inhibit JNK2.
CSN19212 Pexmetinib 945614-12-0 Pexmetinib is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line.
CSN13817 PD 169316 152121-53-4 PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).
CSN19013 Pamapimod 449811-01-2 Pamapimod is a selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 mM, respectively with no activity against p38delta or p38gamma isoforms.
CSN17386 p38 MAPK-IN-1 1006378-90-0 p38 MAPK-IN-1 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM, shows sustained levels, low clearance and good bioavailability.
CSN20238 NJK14047 1800576-41-3 NJK14047 is a selective biphenyl amide p38 MAPK inhibitor which can be used in anti-viral approach targeting hepatitis B virus.
CSN14542 Neoechinulin A 51551-29-2 Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
CSN22457 MAPK13-IN-1 229002-10-2 MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM.
CSN23347 Methyl 3-(4-hydroxy-3-methoxyphenyl)acrylate 2309-07-1 Methyl Ferulate is a naturally-occurring phenolic with antioxidant activities and inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.
CSN16041 5-(2-(tert-Butyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate 862507-23-1 LY2228820 is a potent p38MAPK inhibitor with IC50 of 7 nM and 3 nM for p38αMAPK and p38βMAPK.
CSN18346 Losmapimod 585543-15-3 Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
CSN22233 N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride 1252679-52-9 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
CSN22404 1-(7-(4-Fluorophenyl)-8-(pyridin-4-yl)-3,4-dihydropyrazolo[5,1-c][1,2,4]triazin-2(1H)-yl)-2-phenylethane-1,2-dione sulfate 158876-66-5 FR-167653 is a selective p38 MAPK inhibitor.
CSN22405 FR 167653 Free Base 158876-65-4 FR-167653 is a selective p38 MAPK inhibitor.
CSN25661 Dilmapimod 444606-18-2 Dilmapimod is a selective p38 MAPK inhibitor. It is used in neuropathic pain and acute respiratory distress syndrome.
CSN19850 (2R,2'S,3R,5R,5aR,6S,9aR)-3,6-Dihydroxy-5a-(hydroxymethyl)-5,8-dimethyl-2,3,4,5,5a,6-hexahydrospiro[2,5-methanobenzo[b]oxepine-10,2'-oxiran]-7(9aH)-one 51481-10-8 Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor.
CSN19015 Dehydrocorydaline chloride 10605-03-5 Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities.
CSN19908 Cornuside 131189-57-6 Cornuside, a natural product isolated and purified from the fruits of Cornus officinalis Sieb.
CSN26344 CMPD1 41179-33-3 CMPD1 is a selective inhibitor of non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation with apparent Ki (Kiapp) of 330 nM.
CSN20299 CBS-3595 452056-93-8 CBS-3595 is a dual p38α MAPK/PDE-4 inhibitor with activity against TNFα -related diseases.
CSN18737 BMS-582949 623152-17-0 BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM,inhibiting both p38 kinase activity and activation of p38.
CSN18566 BMS-582949 HCl 912806-16-7 BMS-582949 HCl is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.
CSN22119 AZD7624 1095004-78-6 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
CSN22609 AZ304 942507-42-8 AZ304 is an inhibitor of BRAF and can target many kinases. The IC50s for wild type BRAF, V600E mutant BRAF and wild type CRAF are 79 nM, 38 nM and 68 nM, respectively. It can also inhibit p38 (IC50 = 6 nM) and CSF1R (IC50 = 35 nM).
CSN19454 Asiatic acid 464-92-6 Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, commonly used in wound healing by increasing collagen production.
CSN19014 Acumapimod 836683-15-9 Acumapimod is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
CSN24901 Dihydrocaffeic acid 1078-61-1 3,4-Dihydroxyhydrocinnamic acid is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties.
CSN75999 EO 1428 321351-00-2
CSN79676 CHMFL-ABL-053 1808287-83-3
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