|Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60% at 2 and 10μM and had no effect at 0.08 and 0.4μM (measured by P-gp ATPase activity).
|Zosuquidar 3HCl is the 3HCl form of Zosuquidar. Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60% at 2 and 10μM and had no effect at 0.08 and 0.4μM.
|Valspodar is a P-glycoprotein (P-gp) inhibitor widely used in preclinical and clinical studies for overcoming multidrug resistance (MDR).
|Taxinine B, a natural product isolated and purified from the barks of Taxus chinensis, can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells, and shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
|Tariquidar methanesulfonate, hydrate
|Tariquidar methanesulfonate is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
|Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM, reverses drug resistance in MDR cell Lines.
|Sinapine, an alkaloid isolated and purified from the seeds of Raphanus sativus L., possess antioxidant and radio-protective activities, downregulats multi-drug resistance 1 (MDR1) expression.
|Sinapine is an alkaloid from seeds of the cruciferous species which shows antioxidant and radio-protective activities and decreases expression of P-glycoprotein in Caco-2 cells.
|Schizandrin is a natural product possessing antioxidant and anti-inflammatory activities.
|SC144 showed its function through both exhibiting potent cytotoxicity, by itself or synergism with other compounds, against a panel of drug-sensitive and drug-resistant cancer cell lines, and targeting to gp130.
|SC144 HCl is the first-in-class orally active small-molecule gp130 inhibitor (IC50 = 0.72 μM) which blocks cytokine-triggered gp130 signaling.
|RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
|Phyllanthin, a natural product isolated and purified from the herb of Phyllanthus niruri L., is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
|Isosinensetin exhibits HIV-1 protease inhibiting and antioxidant activities. It is a natural product isolated and purified from the fruit of Citrus aurantium L..
|HM30181 is a potent and selective inhibitor of P-glycoprotein.
|GP130 receptor agonist-1
|gp130-agonist-2 is a brain penetrant gp130 agonist which protects against NMDA-induced toxicity and increases STAT3 phosphorylation.
|Epimedokoreanin B is a natural product isolated and purified from the herbs of Epimedium brevicornum.
|Elacridar is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
|Elacridar HCl is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-gp to investigate the role of transporters in the disposition of various test molecules.
|Dofequidar is a quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.
|Dofequidar fumarate, an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.
|CP 100356 HCl is a high affinity P-glycoprotein (P-gp) inhibitor with Kis of 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms.