OPA1 (OPA1 Mitochondrial Dynamin Like GTPase) is a Protein Coding gene. Diseases associated with OPA1 include Optic Atrophy 1 and Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include GTP binding and magnesium ion binding. An important paralog of this gene is DNM2.
|MYLS22 is a first-in-class small molecule-specific OPA1 inhibitor which inhibits tumor angiogenesis, impacts tumor growth and metastatization dependent on NFκB pathway.