|2-(tert-Butyl)benzene-1,4-diol(may occur to produce black solid)
|TBHQ is a synthetic aromatic organic compound used as an antioxidant and preservative.
|RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 by binding KEAP1 and inhibits the proinflammatory transcription factor NF-κB.
|RA-839 is a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. RA-839 also suppresses LPS-induced iNOS and nitric oxide expression in macrophages.
|Nrf2 pathway activator; blocks Nrf2/Keap1 interaction
|NK-252 is a Nrf2 activator, exhibits a greater Nrf2-activating potential than OPZ.
|MMF can induce Nrf2 activation.
|ML-385 is a selective inhibitor of NRF2 via binding to Neh1 DNA binding domain with IC50 of 1.9 µM.
|KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.
|Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.
|Ginsenoside Rh3, a natural product isolated and purified from the roots of Panax ginseng C.
|Farrerol is a natural product isolated and purified from the leaves of Rhododendron dauricum L.
|Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe.
|Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator which induces upregulation of antioxidant gene expression.
|CDDO-EA is an activator of Nrf2/ARE with neuroprotective effect.
|AKBA is a novel Nrf2 activator which can increase basal and UVA-induced levels of Nrf2.
|AI-3 is an antivator of antioxidant response element (ARE). It can disrupt Nrf2/Keap1 and Keap1/Cul3 interactions and stabilize Nrf2.
|4-Octyl itaconate is the endogenous metabolite of itaconate with anti-inflammatory activity. It can decrease cytokine production and protect against lipopolysaccharide-induced lethality in vivo.