|tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notchsignaling.
|Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
|SAHM1 is a stabilized hydrocarbon-stapled alpha helical peptide targeting Notch pathway. It mimics a dominant negative form of MAML, inhibits canonical Notch transcription complex formation.
|RIN1 is a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ. It also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling.
|Medicarpin, a natural product isolated and purified from the herb of Hedysarum polybotrys Hand. Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways.
|LY3039478 is a novel, potent Notch inhibitor with an IC50 of 0.41 nM.
|IMR-1A is the metabolite of IMR-1, a Notch inhibitor targeting the transcriptional activation.
|IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex with IC50 of 6 μM for targeting the transcriptional activation.
|FLI-06 is a Notch signaling inhibitor with EC50 of 2.3 μM which can disrupt Notch trafficking and processing.
|CB-103 is a first-in-class orally active pan-notch signaling pathway inhibitor extracted from patent US9296682B2 with anti-tumor activity.
|BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.