|SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.
|ETC-206 is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively.
|eFT508 is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.
|CGP-57380 is a selective Mnk1 inhibitor with IC50 value of 2.2 μM.
|Cercosporamide is a potent and selective Mnk inhibitor, and an orally bioavailable antifungal agent, suppresses phosphorylation of eIF4E and exhibits antileukemic effects.