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Metabolic Disease

货号 产品名 CAS号 信息
CSN22127 GLX351322 835598-94-2 GLX351322 is an inhibitor of NADPH oxidase 4, inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.
CSN21297 RPR107393 197576-78-6 RPR107393 free base is a selective squalene synthase inhibitor, which inhibits rat liver microsomal squalene synthase with an IC50 of 0.8±0.2 nM.
CSN21243 KI696 1799974-70-1 KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.
CSN21233 ND-646 1434639-57-2 ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth.
CSN21246 YM-53601 free base 182959-28-0 YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents.
CSN21268 SB-568849 395679-53-5 SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7.
CSN21267 YM348 372163-84-3 YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM).
CSN21271 NGD-4715 476322-70-0 NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist .
CSN21282 MCHR1 antagonist 2 863115-70-2 MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.
CSN21257 FR194738 free base 204067-45-8 FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
CSN21311 RP 73163 Racemate 136609-53-5 RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
CSN21260 Vildagliptin dihydrate 2133364-01-7 Vildagliptin (LAF237 dihydrate;NVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1).
CSN22131 Cort108297 1018679-79-2 Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM.
CSN22344 AM-1638 1142214-62-7 AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM.
CSN22486 PF-06471553 1808094-07-6 PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.
CSN22133 W146 909725-61-7 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
CSN22389 E-5324 141799-76-0 E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM.
CSN22522 TR antagonist 1 500794-88-7 TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
CSN22112 Lodelaben 111149-90-7 Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
CSN22439 JTT 551 776309-04-7 JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.
CSN22510 Sograzepide 155488-25-8 Sograzepide is a gastrin/cholecystokinin 2 receptor (CCK2) antagonist.
CSN22122 Monacolin J 79952-42-4 Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
CSN22411 GI 181771 305366-98-7 GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.
CSN21375 TES-1025 1883602-21-8 TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13±3 nM.
CSN21415 LMPTP inhibitor 1 HCl 2310135-38-5 LMPTP Inhibitor 1 HCl is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
CSN21353 Edasalonexent 1204317-86-1 Edasalonexent is an orally bioavailable NF-κB inhibitor.
CSN21395 PF-06869206 2227425-05-8 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
CSN21411 LMPTP inhibitor 1 2HCl 2310135-46-5 LMPTP INHIBITOR 1 2HCl is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
CSN21357 YK11 1370003-76-1 YK11 is a partial agonist of androgen receptor, with osteogenic activity.
CSN22162 FK-448 Free base 85858-76-0 FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
CSN21399 Saikogenin A 5092-09-1 Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.
CSN22165 PTP1B-IN-3 809272-64-8 PTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively.
CSN22185 Elobixibat 439087-18-0 Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT.
CSN22198 LY377604 204592-94-9 LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. Ly377604 has been used in trials studying the treatment of Obesity.
CSN22243 SNT-207858 1104080-42-3 SNT-207858 is a non-peptide, orally active melanocortin MC-4 receptor antagonist penetrating the blood brain barrier.
CSN22244 XEN723 1072803-08-7 XEN723 is a potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
CSN22236 GPR120 Agonist 2 1234844-11-1 GPR120 Agonist 2 is a GPR120 agonist extracted from patent US 20110313003 A1, example 209.
CSN22218 S-8921 151165-96-7 S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.
CSN22239 BMS-819881 1197420-05-5 BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.
CSN22397 Ertiprotafib 251303-04-5 Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β), an EC50 of ~1 μM for PPARα/PPARβ.
CSN22413 GLPG0974 1391076-61-1 GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC50 of 9 nM.
CSN22367 CDK8-IN-3 1884500-15-5 CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7.
CSN22395 EPAC 5376753 302826-61-5 EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
CSN22408 GC 14 447415-34-1 GC 14 is a selective agonist of thyroid hormone β1 activation (TRβ1) with an EC50 of 680 nM.
CSN22489 Mavodelpar free acid 942594-93-6 PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10.
CSN22533 Velagliflozin 946525-65-1 Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.
CSN22490 Pparδ agonist 1 1902161-12-9 Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
CSN22513 SR 146131 221671-61-0 GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.
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