|SR9243 is a LXR inverse agonist that induces LXR-corepressor interaction and shows anticancer activity and selectively targets the warburg effect and lipogenesis.
|SR9238 is a potent synthetic LXR antagonist with IC50s of 214 nM and 43 nM for LXRα and LXRβ respectively.
|Rovazolac is a modulator of liver x receptor (LXR).
|RGX104 free acid is an agonist of liver-X nuclear hormone receptor (LXR), it can regulate the immune process by activating the ApoE gene.
|RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
|LXR-623 is a novel and brain-penetrant LXR agonist with IC50 values of 179 and 24 nM for LXRα and LXRβ, respectively.
|GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively.
|2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid hydrochloride
|GW3965 HCl is a selective and non-steroidal LXR agonist with EC50 values of 190 and 30 nM for hLXRα and hLXRβ, respectively.
|GSK 2033 is a potent LXR antagonist with pIC50 of 7.5.
|Ethyl 2,4,6-trihydroxybenzoate, a natural product isolated and purified from the herbs of Celtis biondii, suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes, and is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.
|BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.
|AZ876 is a high-affinity LXR agonist.
|27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.