|Rocaglamide, a naturally occurring product isolated from the herbs of Aglaia odorata Lour, induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients.
|HSF1A is an activator of Heat shock transcription factor 1 (HSF1).
|Geniposidic Acid is a naturally occuring iridoid glucoside HSF1 inducer, with anti-inflammatory and anti-cancer agent.
|CCT251236 is a HSF1 pathway inhibitor with IC50 value of 19nM for inhibition of HSF1-mediated HSP72 induction, and a tight-binding ligand of pirin with Kd value of 44nM. It displays efficacy in a human ovarian carcinoma xenograft model.