G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
|YM-254890 works as both a selective inhibitor of the Gq protein subfamily and a novel platelet aggregation inhibitor with IC50 value below 0.6μM by blocking the P2Y1 receptor-signal transduction pathway. It isolated from the culture broth of strain QS3666.
|PH-064 is a sodium channel inhibitor. It is also a selective Gαq inhibitor. It traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry.
|Mas7, structural analogue of mastoparan isolated from wasp venom, is an activator of G protein via Gαi and Gαo stimulation.
|FR900359 is a plant-derived depsipeptide which works as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms. It suppresses many of the hallmark features that are central to the malignancy of melanoma cells.
|0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP.