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Endothelin Receptor

Endothelin Receptor

货号 产品名 CAS号 信息
CSN13675 Zibotentan 186497-07-4 Zibotentan is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
CSN29551 ZD-1611 186497-38-1 ZD1611 is an endothelin receptor antagonist.
CSN12014 4-Amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide 127-69-5 Sulfisoxazole is an antagonist of endothelin receptor that can be used as a sulfonamide antibacterial agent.
CSN11008 Sodium ferulic 24276-84-4 Sodium ferulate is the sodium salt of ferulic acid which is used for the treatment of cardiovascular disease.
CSN12974 Sitaxsentan sodium 210421-74-2 Sitaxsentan sodium has selectory antagonism of endothelin A (ETA) receptor with the IC50 and Ki value of 1.4 nM and 0.43 nM respectively.
CSN12975 Sitaxsentan 184036-34-8 Sitaxsentan is a selective endothelin A (ETA) receptor antagonist.
CSN24483 Ro 46-8443 175556-12-4 Ro 46-8443 is the first non-peptide Endothelin Receptor B selective antagonist with IC50 value of 110nM.
CSN17902 Ro 46-2005 150725-87-4 Ro 46-2005 is an antagonist of endothelin receptor.
CSN18333 Macitentan (n-butyl analogue) 556797-16-1 Macitentan n-butyl analogue is a n-butyl analogue of Macitentan (ACT064992), which is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
CSN13736 N-(5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N'-propylsulfamide 441798-33-0 Macitentan is an antagonist of endothelin receptor A (ETA) with IC50 of 0.5 nM. It is developed for treatment of pulmonary arterial hypertension (PAH).
CSN25744 IRL 2500 169545-27-1 IRL-2500 is a potent endothelin receptor antagonist with IC50 values of 1.3 and 94 nM for ETB and ETA receptors respectively.
CSN20320 HJP272 1072467-37-8 HJP272, an endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury.
CSN25742 Endothelin-2 (49-69), human 123562-20-9 Endothelin 2 (human) is endogenous peptide found predominately in the kidney and intestine. Endothelin 2 displays similar selectivity for ETA and ETB endothelin receptors.
CSN21629 Endothelin 1 (swine, human) 117399-94-7 Endothelin 1 (human, porcine) is a peptide vasoconstrictor and agonist of endothelin (ET) receptors ETA and ETB.
CSN23533 Darusentan 171714-84-4 Darusentan is an antagonist of endothelin ETA receptor and it can be used to treat congestive heart failure and hypertension.
CSN19760 Clazosentan 180384-56-9 Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury.
CSN17348 BQ-788 sodium salt 156161-89-6 BQ-788 sodium salt is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM.
CSN18010 BQ-788 173326-37-9 BQ-788 is a potent and selective endothelin receptor subtype B (ETB) antagonist with IC50 of 1.2 nM (inhibits 125I-labeled endothelin 1 (ET-1) binding to ETB receptors on human Girardi heart cells).
CSN17753 BQ-123 136553-81-6 BQ-123 is a specific antagonist of endothelin A receptor (ETA) and the IC50 is 7.3 nM.
CSN10481 4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide hydrate 157212-55-0 Bosentan is an endothelin (ET) receptor antagonist of ET-A (Ki = 4.7 nM) and ET-B (Ki = 95 nM).
CSN10480 Bosentan 147536-97-8 Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
CSN25558 BMS 182874 hydrochloride 1215703-04-0 BMS 182874 Hydrochloride is a potent and selective and competitive non-peptide endothelin ETA receptor antagonist with Ki of 48 nM.
CSN12872 Avosentan 290815-26-8 Avosentan is a potent, selective endothelin receptor (ETA receptor) antagonist.
CSN23856 Carperitide acetate 1366000-58-9 Atrial Natriuretic Peptide (1-28), human, porcine Acetate is a 28-amino acid hormone, it is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. It inhibits endothelin-1 secretion in a dose-dependent way.
CSN18015 Atrasentan 173937-91-2 Atrasentan is an endothelin receptor antagonist (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN13753 Atrasentan HCl 195733-43-8 Atrasentan HCl is an endothelin receptor antagonist (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
CSN10496 Ambrisentan   177036-94-1 Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively).
CSN17466 Aprocitentan 1103522-45-7 ACT-132577 is the major and pharmacologically active metabolite of macitentan), which is dual ETA/ETB endothelin (ET) receptor antagonist designed for tissue targeting.
CSN25741 A 127722 195704-72-4 A 127722 is a potent ETA endothelin receptor antagonist with IC50 values of 0.11 nM and 98 nM for human ETA and ETB receptors, respectively.
CSN28996 Sparsentan 254740-64-2
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