|YM 511 is an orally active, potent aromatase (CYP19) inhibitor with IC50 of 0.4 and 0.12 nM at rat ovary and human placenta cells respectively.
|Urolithin B is a natural product with anti-proliferative and antioxidant activity, which can penetrate the blood-brain barrier and may have neuroprotective effects against Alzheimer’s Disease.It inhibits aromatase activity in human placental microsomes and aromatase-sensitive MCF-7 (MCF-7aro) human breast cancer cells when used at concentrations of 47 and 4.7 µM, respectively.
|Obacunone, a natural product isolated and purified from the barks of Phellodendron chinense, has cytotoxicity in androgen-dependent human prostate cancer cells. Obacunone may have the potential to prevent estrogen-responsive breast cancer through inhibition of the aromatase enzyme and inflammatory pathways, as well as activation of apoptosis.
|Fadrozole is a selective aromatase inhibitor that has been introduced in Japan for the treatment of breast cancer.
|Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively.
|Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity.