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Topoisomerase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN10116 | Valrubicin | 56124-62-0 | Valrubicin is a chemotherapy drug used to treat bladder cancer. |
| CSN10393 | 5-Nitroquinolin-8-ol | 4008-48-4 | Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections. |
| CSN10001 | (S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid | 100986-85-4 | Levofloxacin is an inhibitor of type II topoisomerases. It can inhibit DNA gyrase and topoisomerase IV with IC50 of 8.06 µg/ml and 9.81 µg/ml. It is an antibacterial agent. |
| CSN11026 | 9-Fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid | 42835-25-6 | Flumequine is a topoisomerase II inhibitor with IC50 of 15 μM. It is a synthetic chemotherapeutic antibiotic. |
| CSN10918 | Epirubicin | 56420-45-2 | Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting topoisomerase. |
| CSN10908 | 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 74011-58-8 | Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. |
| CSN10807 | 6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride | 91296-86-5 | Difluoxacin HCl is a quinolone antimicrobial antibiotic and an inhibitor of Topo II. |
| CSN10750 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione | 20830-81-3 | Daunorubicin, a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. |
| CSN10163 | Clinafloxacin | 105956-97-6 | Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. |
| CSN10463 | Bisantrene | 78186-34-2 | Bisantrene is a highly effective antitumor drug, targets eukaryotic typeII topoisomerases. |
| CSN10306 | N-(4-(Acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide hydrochloride | 54301-15-4 | Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells. |
| CSN10305 | Amrubicin | 110267-81-7 | Amrubicin is an anthracycline derivative for treatment of bladder carcinoma. |
| CSN10293 | Amonafide | 69408-81-7 | Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
| CSN10176 | 7-Ethylcamptothecin | 78287-27-1 | 7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase). |
| CSN10390 | (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 19685-09-7 | (S)-10-hydroxycamptothecin is an inhibitor of DNA topoisomerase I with antitumor activity. |
