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Secretase

Secretase

货号 产品名 CAS号 信息
CSN11079 Z-Ile-Leu-aldehyde 161710-10-7 Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor.
CSN18740 Verubecestat 1286770-55-5 Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
CSN16034 RO4929097 847925-91-1 RO4929097 is an inhibitor of γ secretase, the IC50s of Aβ40 and notch are 14 nM and 5 nM, respectively.
CSN17660 Nirogacestat 1290543-63-3 PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM.
CSN17132 LY-411575 209984-57-6 LY411575 is an inhibitor of γ-secretase with IC50 of 0.078 nM and it can also inhibit Notch clevage (IC50 = 0.39 nM).
CSN17134 LY2886721 1262036-50-9 LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
CSN12810 LY2811376 1194044-20-6 LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
CSN18101 LY-411575 isomer 1 209984-58-7 LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM.
CSN17284 L-685458 292632-98-5 L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM.
CSN18608 gamma-Secretase Modulators 937812-80-1 gamma-Secretase modulators is an Amyloid-β production inhibitor, useful for Alzheimer's disease.
CSN17843 gamma-secretase modulator 3 1431697-84-5 gamma-Secretase modulator 3 is a gamma-secretase modulator.
CSN17461 gamma-secretase modulator 2 1093978-89-2 gamma-Secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease.
CSN17513 gamma-secretase modulator 1 1172637-87-4 gamma-Secretase modulator 1 is a gamma-secretase modulator useful for Alzheimer's disease.
CSN17015 E 2012 870843-42-8 E 2012 is a potent γ-secretase modulator.
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN13896 DAPT   208255-80-5 DAPT is an inhibitor of γ-secretase and it can reduce the expression of Aβ40 and Aβ42 with IC50 values of 115 nM and 200 nM.
CSN16335 Itanapraced 749269-83-8 CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
CSN18659 Lanabecestat 1383982-64-6 AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
CSN12379 Avagacestat 1146699-66-2 Avagacestat is an inhibitor of γ-secretase Aβ40 and Aβ42 with IC50s of 0.3 nM and 0.27 nM, respectively.
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