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Secretase
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN11079 | Z-Ile-Leu-aldehyde | 161710-10-7 | Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor. |
CSN18740 | Verubecestat | 1286770-55-5 | Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. |
CSN16034 | RO4929097 | 847925-91-1 | RO4929097 is an inhibitor of γ secretase, the IC50s of Aβ40 and notch are 14 nM and 5 nM, respectively. |
CSN17660 | Nirogacestat | 1290543-63-3 | PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM. |
CSN17132 | LY-411575 | 209984-57-6 | LY411575 is an inhibitor of γ-secretase with IC50 of 0.078 nM and it can also inhibit Notch clevage (IC50 = 0.39 nM). |
CSN17134 | LY2886721 | 1262036-50-9 | LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. |
CSN12810 | LY2811376 | 1194044-20-6 | LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. |
CSN18101 | LY-411575 isomer 1 | 209984-58-7 | LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM. |
CSN17284 | L-685458 | 292632-98-5 | L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM. |
CSN18608 | gamma-Secretase Modulators | 937812-80-1 | gamma-Secretase modulators is an Amyloid-β production inhibitor, useful for Alzheimer's disease. |
CSN17843 | gamma-secretase modulator 3 | 1431697-84-5 | gamma-Secretase modulator 3 is a gamma-secretase modulator. |
CSN17461 | gamma-secretase modulator 2 | 1093978-89-2 | gamma-Secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease. |
CSN17513 | gamma-secretase modulator 1 | 1172637-87-4 | gamma-Secretase modulator 1 is a gamma-secretase modulator useful for Alzheimer's disease. |
CSN17015 | E 2012 | 870843-42-8 | E 2012 is a potent γ-secretase modulator. |
CSN13122 | YO-01027 | 209984-56-5 | Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. |
CSN13896 | DAPT | 208255-80-5 | DAPT is an inhibitor of γ-secretase and it can reduce the expression of Aβ40 and Aβ42 with IC50 values of 115 nM and 200 nM. |
CSN16335 | Itanapraced | 749269-83-8 | CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively. |
CSN18659 | Lanabecestat | 1383982-64-6 | AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. |
CSN12379 | Avagacestat | 1146699-66-2 | Avagacestat is an inhibitor of γ-secretase Aβ40 and Aβ42 with IC50s of 0.3 nM and 0.27 nM, respectively. |