TG 100713 | PI3K抑制剂 | 现货供应

CAS No.: 925705-73-3

TG 100713 Catalog No. CSN16414

Synonyms: TG 100713

TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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400-920-2911

sales@csnpharm.cn

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 PI3Kα

IC50:165nM PI3Kβ

IC50:215nM PI3Kδ

IC50:24nM PI3Kγ

IC50:50nM
描述The phosphoinositide 3-kinase (PI3K) signaling pathway plays a central role in regulating cell growth, proliferation, survival, angiogenesis, metabolism, and motility^[2]. The class I PI3-Ks (p110α, p110β, p110δ, and p110γ) are activated by tyrosine kinases or G protein-coupled receptors to generate PIP3, which engages downstream effectors such as the Akt/PDK1 pathway, the Tec family kinases, and the Rho family GTPases^[3]. TG100713 is a pan-PI3K inhibitor with IC₅₀s of 50 nM, 24 nM, 165 nM and 215 nM for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ, respectively. In a vitro study, TG 100713 at 10 M strongly inhibited human umbilical vein endothelial cell proliferation^[4].
参考文献

[1] Doukas J, Wrasidlo W, et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.
[2] Yuan J, Mehta PP, Yin MJ, Sun S, Zou A, Chen J, Rafidi K, Feng Z, Nickel J, Engebretsen J, Hallin J, Blasina A, Zhang E, Nguyen L, Sun M, Vogt PK, McHarg A, Cheng H, Christensen JG, Kan JL, Bagrodia S. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther. 2011 Nov;10(11):2189-99. doi: 10.1158/1535-7163.MCT-11-0185. Epub 2011 Jul 12. PMID: 21750219.
[3] Martin KJ, Muessel MJ, Pullar CE, Willars GB, Wardlaw AJ. The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels. PLoS One. 2015 Feb 6;10(2):e0116250. doi: 10.1371/journal.pone.0116250. Erratum in: PLoS One. 2015;10(7):e0134924. PMID: 25659107; PMCID: PMC4320071.
[4] Doukas J, Wrasidlo W, Noronha G, Dneprovskaia E, Fine R, Weis S, Hood J, Demaria A, Soll R, Cheresh D. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71. doi: 10.1073/pnas.0606956103. Epub 2006 Dec 15. PMID: 17172449; PMCID: PMC1702529.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9332 mL
- 19.6659 mL
- 39.3318 mL
- 5 mM
- 0.7866 mL
- 3.9332 mL
- 7.8664 mL
- 10 mM
- 0.3933 mL
- 1.9666 mL
- 3.9332 mL

技术信息

CAS号

925705-73-3

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H10N6O

运输

蓝冰

分子量

254.25

别名

TG 100713

溶解度

DMSO	2.0 mg/mL (7.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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靶点	Description	IC50
PI3Kα		IC50:165nM
PI3Kβ		IC50:215nM
PI3Kδ		IC50:24nM
PI3Kγ		IC50:50nM

TG 100713 Catalog No. CSN16414

靶点选择性

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