487-36-5|Pinoresinol|CsnPharm

CAS No.: 487-36-5

Pinoresinol Catalog No. CSN12281

Synonyms: (+)-Pinoresinol;NSC 35444;(+)-松脂素

Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides Oliver, may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C.

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生物活性

描述Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides Oliver, may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C^[3]. Pinoresinol (25 mg/kg, p.o.) ameliorated memory impairment in dementia model induced by cholinergic blockade in the passive avoidance test in a dose-dependent manner. Moreover, pinoresinol (50 μM) facilitated induction of hippocampal long-term potentiation, a cellular model of learning and memory. Pinoresinol blocked acetylcholinesterase (AchE), an acetylcholine-degrading enzyme, activity in a concentration-dependent manner. Moreover, pinoresinol (50 μM) facilitated calcium influx into neuro2a cell^[4]. Oral administration of pinoresinol ameliorated Aβ-induced memory deficits without sensory dysfunction^[5]. Pinoresinol attenuates inflammatory responses of microglia and could be potentially useful in modulation of inflammatory status in brain disorders^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01619020	Healthy	Not Applicable	Completed	-	United States, Washington ... more >> FHCRC Seattle, Washington, United States, 98109 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7903 mL
- 13.9515 mL
- 27.9029 mL
- 5 mM
- 0.5581 mL
- 2.7903 mL
- 5.5806 mL
- 10 mM
- 0.2790 mL
- 1.3951 mL
- 2.7903 mL

技术信息

CAS号	487-36-5	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C20H22O6	运输	蓝冰
分子量	358.39	别名	(+)-Pinoresinol;NSC 35444;(+)-松脂素

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