CAS No.: 402473-54-5
ONO-AE3-208 Catalog No. CSN18259
Synonyms: AE 3-208
ONO-AE3-208 is an antagonist of EP4 with Ki of 1.3 nM and exhibits suppression the invasion and metastasis of prostate cancer cells.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Xu S, Zhang Z, et al. An EP4 antagonist ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer. Cell Biochem Biophys. 2014 Sep;70(1):521-7.
- [2] Ren Y, D'Ambrosio MA, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8.
- [3] Xu S, Zhang Z, Ogawa O, Yoshikawa T, Sakamoto H, Shibasaki N, Goto T, Wang L, Terada N. An EP4 antagonist ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer. Cell Biochem Biophys. 2014 Sep;70(1):521-7
- [4] Gervin E, Shin B, Opperman R, Cullen M, Feser R, Maiti S, Majumder M. Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer. Cancers (Basel). 2020 Jul 22;12(8):2008
- [5] Aringer I, Artinger K, Kirsch AH, Schabhüttl C, Jandl K, Bärnthaler T, Mooslechner AA, Herzog SA, Uhlig M, Kirsch A, Frank S, Banas M, Pollheimer M, Eller P, Rosenkranz AR, Heinemann A, Eller K. Blockade of prostaglandin E2 receptor 4 ameliorates nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1869-F1880
- [6] Mizoguchi S, Wolf-Johnson AS, Ni J, Mori K, Suzuki T, Takaoka E, Mimata H, DeFranco DB, Wang Z, Birder LA, Yoshimura N. The role of prostaglandin and E series prostaglandin receptor type 4 receptors in the development of bladder overactivity in a rat model of chemically induced prostatic inflammation. BJU Int. 2019 Nov;124(5):883-891
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 402473-54-5 | 储存条件 |
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| 分子式 | C24H21FN2O3 | 运输 | 蓝冰 | |||||
| 分子量 | 404.43 | 别名 | AE 3-208 | |||||
| 溶解度 |
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动物实验配方 |
