32795-47-4|Nomifensine maleate|CsnPharm

CAS No.: 32795-47-4

Nomifensine maleate/诺米芬新马来酸盐 Catalog No. CSN11571

Synonyms: (±)-Nomifensine maleat;(±)-Nomifensine Maleate;Nomifensine Maleate

Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

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生物活性

描述Nomifensine Maleate (Nomifensine) is an isoquinoline antidepressant that inhibits the reuptake of dopamine at central synapses. It also inhibits norepinephrine reuptake but is only a weak inhibitor of 5-hydroxytryptamine^[3]. Nomifensine is a safe and effective antidepressant with a fairly unique pharmacological profile^[4]. Short-term use of nomifensine was relatively free from side effects and was remarkably effective in the treatment of ADD(attention deficit disorder)-RT(residual type)^[5]. Nomifensine and some of its structural analogues produce behavioral effects indicative of indirect dopaminergic agonist properties, such as hyperlocomotion. Both PTIQ (nomifensine analogue 4-phenyl-1,2,3,4-tetrahydroisoquinoline) and nomifensine significantly augmented METH-induced stereotypical behavior and locomotion in mice^[6]. Nomifensine elevates the tone of rapid dopamine signals in the brain^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8217 mL
- 14.1084 mL
- 28.2167 mL
- 5 mM
- 0.5643 mL
- 2.8217 mL
- 5.6433 mL
- 10 mM
- 0.2822 mL
- 1.4108 mL
- 2.8217 mL

技术信息

CAS号

32795-47-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22N2O4

运输

蓝冰

分子量

354.40

别名

(±)-Nomifensine maleat;(±)-Nomifensine Maleate;Nomifensine Maleate;诺米芬新马来酸盐

溶解度

DMSO	78.0 mg/mL (220.1 mM) warming
Water	2.0 mg/mL (5.6 mM) warming

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Nomifensine maleate/诺米芬新马来酸盐 Catalog No. CSN11571

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