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CAS No.: 83280-65-3
Synonyms: BBI608
Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3.
生物活性
动物研究 | |
剂量 | Mice: 40 mg/kg[3] (i.p.) |
给药途径 | i.p. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT02232646 | Urologic Malignancies ... more >> Renal Cell Carcinoma Urothelial Carcinoma Collapse << | Phase 2 | Withdrawn(Low feasibility) | - | - |
NCT03416816 | Neoplasms | Phase 1 | Recruiting | June 2020 | United States, Indiana ... more >> Indiana University Health Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 United States, Michigan Karmos Cancer Center Recruiting Detroit, Michigan, United States, 48201 United States, Texas UT Heatlh San Antonio Recruiting San Antonio, Texas, United States, 78229 United States, Utah Utah Cancer Specialist Recruiting West Jordan, Utah, United States, 84088 Collapse << |
NCT02347917 | Malignant Pleural Mesothelioma... more >> Non-Small Cell Lung Cancer Collapse << | Phase 1 Phase 2 | Completed | - | Japan ... more >> National Cancer Center Hospital East Chiba, Japan National Cancer Center Hospital Tokyo, Japan Collapse << |
实验方案
技术信息
CAS号 | 83280-65-3 | 储存条件 |
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分子式 | C14H8O4 | 运输 | 蓝冰 | |||||||||||
分子量 | 240.21 | 别名 | BBI608 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human DU145 cells | - | Function assay | 72 h | Anticancer activity against human DU145 cells after 72 hrs by XTT assay, IC50=0.02304 μM | 18829316 |
human HaCaT cells | - | Function assay | 48 h | Antihyperproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopy, IC50=0.5 μM | 22845014 |
human HaCaT cells | - | Proliferation assay | - | Antiproliferative activity against human HaCaT cells, IC50=0.5 μM | 10479319 |
KB cells | - | Cytotoxic assay | - | Effective cytotoxic dose against KB cells was evaluated, ED50=4.2 μM | 9873618 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02232646 | Urologic Malignancies ... more >> Renal Cell Carcinoma Urothelial Carcinoma Collapse << | Phase 2 | Withdrawn(Low feasibility) | - | - |
NCT03416816 | Neoplasms | Phase 1 | Recruiting | June 2020 | United States, Indiana ... more >> Indiana University Health Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 United States, Michigan Karmos Cancer Center Recruiting Detroit, Michigan, United States, 48201 United States, Texas UT Heatlh San Antonio Recruiting San Antonio, Texas, United States, 78229 United States, Utah Utah Cancer Specialist Recruiting West Jordan, Utah, United States, 84088 Collapse << |
NCT02347917 | Malignant Pleural Mesothelioma... more >> Non-Small Cell Lung Cancer Collapse << | Phase 1 Phase 2 | Completed | - | Japan ... more >> National Cancer Center Hospital East Chiba, Japan National Cancer Center Hospital Tokyo, Japan Collapse << |
NCT02641873 | Metastatic Colorectal Cancer | Phase 1 | Completed | - | Japan ... more >> National Cancer Center Hospital East Kashiwa, Chiba, Japan Aichi Cancer Center Hospital Nagoya, Aichi, Japan Collapse << |
NCT02358395 | Hepatocellular Carcinoma | Phase 1 | Completed | - | Japan ... more >> 4 Sites Tokyo,etc, Japan Collapse << |
NCT01830621 | Colorectal Carcinoma | Phase 3 | Completed | - | - |
NCT03647839 | Colorectal Cancer Metastatic | Phase 2 | Recruiting | August 2022 | Australia, New South Wales ... more >> Border Cancer Hospital Recruiting Albury, New South Wales, Australia, 2640 Contact: Craig Underhill Principal Investigator: Craig Underhill Newcastle Private Hospital Not yet recruiting Newcastle, New South Wales, Australia Contact: James Lynam Northern Cancer Institute Not yet recruiting St Leonards, New South Wales, Australia, 2065 Contact: Nick Pavlakis Principal Investigator: Nick Pavlakis Sydney Adventist Hospital Not yet recruiting Wahroonga, New South Wales, Australia, 2076 Contact: Gavin Marx Principal Investigator: Gavin Marx Westmead Hospital Not yet recruiting Westmead, New South Wales, Australia, 2145 Contact: Adnan Nagrial Principal Investigator: Adnan Nagrial Australia, Queensland Royal Brisbane Hospital Recruiting Herston, Queensland, Australia, 4029 Contact: Matthew Burge Principal Investigator: Matthew Burge Australia, South Australia Flinders Medical Centre Not yet recruiting Bedford Park, South Australia, Australia, 5042 Contact: Chris Karapetis Principal Investigator: Chris Karapetis Ashford Cancer Centre Research Recruiting Kurralta Park, South Australia, Australia, 5037 Contact: Nimit Singhal Principal Investigator: Nimit Singhal Queen Elizabeth Hospital Recruiting Woodville South, South Australia, Australia, 5011 Contact: Tim Price Principal Investigator: Tim Price Australia, Victoria Ballarat Health Service Recruiting Ballarat, Victoria, Australia Contact: Geoffrey Chong Principal Investigator: Geoffrey Chong Eastern Health Not yet recruiting Box Hill, Victoria, Australia Contact: Rachel Wong Monash Health Not yet recruiting Clayton, Victoria, Australia, 3168 Contact: Ben Markman Principal Investigator: Ben Markman Olivia Newton-John Cancer Wellness and Research Centre Recruiting Heidelberg, Victoria, Australia, 3084 Contact: Niall Tebbutt Principal Investigator: Niall Tebbutt Peninsula Health/Frankston Hospital Not yet recruiting Mornington Peninsula, Victoria, Australia Contact: Zee Wang Wong Western Health Recruiting Saint Albans, Victoria, Australia, 3021 Contact: Jeanne Tie Principal Investigator: Jeanne Tie Collapse << |
NCT02467361 | Cancer | Phase 1 Phase 2 | Active, not recruiting | - | United States, Colorado ... more >> University of Colorado Cancer Center Denver, Colorado, United States, 80045 United States, Georgia Emory University Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Illinois University of Chicago Medicine Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York Weill Cornell Medical College New York, New York, United States, 10065 United States, South Carolina Institute for Translational Oncology Research Greenville, South Carolina, United States, 29605 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT01775423 | Cancer, Advanced Malignancies | Phase 1 Phase 2 | Active, not recruiting | April 30, 2019 | United States, South Carolina ... more >> Institute for Translational Oncology Research, Greenville Hospital System Greenville, South Carolina, United States, 29605 Canada, Ontario Ottawa Hospital Cancer Center Ottawa, Ontario, Canada, K1H 8L6 Canada, Quebec Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Collapse << |
NCT02851004 | Metastatic Colorectal Cancer | Phase 1 Phase 2 | Recruiting | April 2021 | Japan ... more >> National Cancer Center Hospital East Recruiting Kashiwa, Chiba, Japan, 277-8577 Contact: Yasutoshi Kuboki, MD +81-4-7133-1111 ext 91400 scoop_core@east.ncc.go.jp Collapse << |
NCT02231723 | Metastatic Pancreatic Adenocar... more >>cinoma Collapse << | Phase 1 | Active, not recruiting | - | United States, Arizona ... more >> Mayo Clinic Arizona Phoenix, Arizona, United States, 85054 United States, Georgia Emory University Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Indiana Parkview Research Center Fort Wayne, Indiana, United States, 46845 Indiana University Health Goshen Center for Cancer Care Goshen, Indiana, United States, 46526 Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Nevada Comprehensive Cancer Centers of Nevada Henderson, Nevada, United States, 89014 United States, Ohio The Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Tennessee The University of Tennessee Medical Center Knoxville, Tennessee, United States, 37920 United States, Texas Texas Oncology - Austin Midtown Austin, Texas, United States, 78705 Texas Oncology - Baylor Charles A. Sammons Cancer Center Dallas, Texas, United States, 75246 Texas Oncology - SAT&BC San Antonio, Texas, United States, 78216 United States, Virginia Virginia Oncology Associates Norfolk, Virginia, United States, 23502 Collapse << |
NCT02352558 | Hematologic Malignancy | Phase 1 | Active, not recruiting | - | United States, Colorado ... more >> Rocky Mountain Cancer Centers Denver, Colorado, United States, 80218 United States, Indiana Indiana University Indianapolis, Indiana, United States, 46202 United States, Tennessee West Clinic Germantown, Tennessee, United States, 38138 United States, Texas Cancer Care Centers of South Texas San Antonio, Texas, United States, 78217 Cancer Care Centers of South Texas - HOAST San Antonio, Texas, United States, 78229 United States, Virginia Virginia Cancer Specialists, P.C. Fairfax, Virginia, United States, 22031 Virginia Oncology Associates Norfolk, Virginia, United States, 23502 United States, Washington Northwest Cancer Specialists, PC Vancouver, Washington, United States, 98684 Collapse << |
NCT02024607 | Advanced Gastrointestinal Canc... more >>er Collapse << | Phase 1 Phase 2 | Active, not recruiting | - | United States, Arizona ... more >> Mayo Clinic Campus in Arizona Phoenix, Arizona, United States, 85054 United States, Florida Florida Cancer Specialists Fort Myers, Florida, United States, 33916 United States, Georgia Emory University Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Indiana Parkview Research Center Fort Wayne, Indiana, United States, 46845 Indiana University Health Goshen Center for Cancer Care Goshen, Indiana, United States, 46526 Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 Indiana University Health Arnett Hospital Lafayette, Indiana, United States, 47905 Indiana University Health Ball Memorial Hospital Muncie, Indiana, United States, 47303 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55901 United States, Ohio Oncology Hematology Care, Inc. Cincinnati, Ohio, United States, 45242 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 Institute for Translational Oncology Research, Greenville Health System Greenville, South Carolina, United States, 29605 United States, Tennessee Tennessee Oncology - Chattanooga Chattanooga, Tennessee, United States, 37404 Tennessee Oncology - Nashville Nashville, Tennessee, United States, 37203 Canada, Ontario Ottawa Hospital Cancer Center Ottawa, Ontario, Canada, K1H 8L6 Collapse << |
NCT01776307 | Colorectal Cancer | Phase 2 | Active, not recruiting | - | United States, Arizona ... more >> Mayo Clinic Scottsdale, Arizona, United States, 85259 United States, Colorado USOR - Rocky Mountain Cancer Center Denver, Colorado, United States, 80218 United States, Florida Mayo Clinic Jacksonville, Florida, United States, 32224 United States, Minnesota USOR - Minnesota Oncology Hematology Minneapolis, Minnesota, United States, 55404 Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio The Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Oregon USOR - Northwest Cancer Specialists Portland, Oregon, United States, 97227 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, South Carolina Institute for Translational Oncology Research, Greenville Hospital System Greenville, South Carolina, United States, 29605 United States, Texas USOR - Texas Oncology Dallas Dallas, Texas, United States, 75246 US Oncology Research The Woodlands, Texas, United States, 77380 USOR - Texas Oncology Tyler Tyler, Texas, United States, 75702 United States, Virginia USOR - Virginia Cancer Specialists Fairfax, Virginia, United States, 22031 Collapse << |
NCT02279719 | Hepatocellular Carcinoma | Phase 1 Phase 2 | Active, not recruiting | - | - |
NCT02178956 | Gastric Cancer ... more >> Gastroesophageal Junction Cancer Collapse << | Phase 3 | Active, not recruiting | June 2019 | - |
NCT02432326 | Cancer Advanc... more >>ed Solid Tumors Collapse << | Phase 1 | Active, not recruiting | - | United States, Illinois ... more >> University of Chicago Medicine Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Indiana Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, New York Weill Cornell Medical College New York, New York, United States, 10065 United States, Texas Texas Oncology - Austin Midtown Austin, Texas, United States, 76104 Texas Oncology - Baylor Charles A. Sammons Cancer Center Dallas, Texas, United States, 75246 Texas Oncology - Fort Worth 12th Ave Fort Worth, Texas, United States, 76104 Texas Oncology, P.A. San Antonio, Texas, United States, 78217 Texas Oncology, P.A. San Antonio, Texas, United States, 78229 Texas Oncology - Tyler Tyler, Texas, United States, 75702 United States, Virginia Virginia Cancer Specialists, PC Fairfax, Virginia, United States, 22031 United States, Washington Northwest Cancer Specialists, PC Vancouver, Washington, United States, 98684 Collapse << |
NCT03721744 | Metastatic Pancreatic Cancer | Phase 3 | Recruiting | December 2021 | China, Jiangsu ... more >> The 81st Hospital of Chinese PLA Recruiting Nanjing, Jiangsu, China Collapse << |
NCT02315534 | Glioblastoma | Phase 1 Phase 2 | Active, not recruiting | - | United States, New York ... more >> Laura and Isaac Perlmutter Cancer Center New York, New York, United States, 10016 Canada, Alberta University of Calgary Calgary, Alberta, Canada Canada, Ontario Princess Margaret Cancer Centre Toronto, Ontario, Canada Collapse << |
NCT02753127 | Colorectal Cancer | Phase 3 | Recruiting | - | - |
NCT02993731 | Carcinoma, Pancreatic Ductal | Phase 3 | Recruiting | - | - |
NCT03522649 | Previously Treated Metastatic ... more >>Colorectal Cancer Collapse << | Phase 3 | Recruiting | November 2021 | China, Guangdong ... more >> Sun Yat-sen University Cancer Center Recruiting Guangzhou, Guangdong, China, 510060 Collapse << |
NCT03411122 | Drug-drug Interactions | Phase 1 | Completed | - | United States, Florida ... more >> Accel Research Sites DeLand, Florida, United States, 32720 Collapse << |
NCT03525405 | ADME Healthy | Phase 1 | Completed | - | United States, Wisconsin ... more >> Covance Clinical Research Unit Madison, Wisconsin, United States, 53704 Collapse << |
NCT02826161 | Carcinoma, Non-Small-Cell Lung | Phase 3 | Terminated(Change of treatment... more >> landscape and evolving standard of care) Collapse << | November 2020 | United States, California ... more >> Beverly Hills, California, United States Santa Rosa, California, United States United States, Florida Aventura, Florida, United States United States, Pennsylvania Gettysburg, Pennsylvania, United States United States, Texas Arlington, Texas, United States Collapse << |
NCT01325441 | Cancer | Phase 1 Phase 2 | Recruiting | - | - |
靶点 | Description | IC50 |
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