1433497-19-8|LY2955303|CsnPharm

CAS No.: 1433497-19-8

LY2955303 Catalog No. CSN20408

Synonyms: LY2955303

LY2955303 is a selective antagonist of RAR-gamma with Ki of 1.09 nM that used to treatm osteoarthritis pain.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述LY2955303 is a potent and selective RARγ antagonist with IC50 of 1.1nM without effect on RARα and RARβ. LY2955303 shows good pharmacokinetic properties with less unacceptable adverse effects on testes compared with pan-RAR antagonist like BMS-189453. A single oral dose of LY2955303 demonstrated a dose responsive effect whereby the mono-iodoacetate rat model, with OA-like joint pain, reduced differential weight bearing (ED50 = 0.72 mg/kg). The toxicity of LY2955303 for testicular degeneration will not be observed until the dose up to 30mg/kg.
动物研究
剂量
Rat: 10 mg/kg - 100 mg/kg^[1] (p.o.)

给药途径
p.o.
参考文献

动物研究
剂量	Rat: 10 mg/kg - 100 mg/kg^[1] (p.o.)
给药途径	p.o.

[1] Hughes NE, Bleisch TJ, et al. Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-7.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7279 mL
- 8.6394 mL
- 17.2788 mL
- 5 mM
- 0.3456 mL
- 1.7279 mL
- 3.4558 mL
- 10 mM
- 0.1728 mL
- 0.8639 mL
- 1.7279 mL

技术信息

CAS号

1433497-19-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C36H42N4O3

运输

蓝冰

分子量

578.74

别名

LY2955303

溶解度

DMSO	30.0 mg/mL (51.8 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

LY2955303 Catalog No. CSN20408

靶点选择性

请登录您的专属账户

确认信息