169545-27-1|((R)-3-([1,1'-Biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan|CsnPharm

CAS No.: 169545-27-1

IRL-2500 is a potent endothelin receptor antagonist with IC50 values of 1.3 and 94 nM for ETB and ETA receptors respectively.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述The ET_B receptor is expressed on vascular endothelial cells where it induces endothelial-dependent vasodilatation through NO production and clearance of circulating ET-1^[1]. IRL 2500, a potent endothelin receptor antagonist, inhibits the binding of [¹²⁵I]-endothelin-1 (ET-1) to human ET_B (IC₅₀ 1.3 ± 0.2 nM) and ET_A (IC₅₀ 94 ± 3 nM) receptors expressed in transfected Chinese hamster ovary (CHO) cells. In in vitro studies, IRL 2500 inhibited the sarafotoxin S6c (STX6c)-mediated contraction of the dog saphenous vein (pKb 7.77) and the STX6c-induced relaxation of the preconstricted rabbit mesenteric artery (pKb 6.92). In the anesthetized rat, IRL 2500 (10 mg/kg, i.v.) inhibited the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 (0.5 nmol/kg, i.v.). IRL 2500 also attenuated the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat^[2].
参考文献

实验方案

技术信息

CAS号	169545-27-1	储存条件	粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C36H35N3O4	运输	蓝冰
分子量	573.68	别名

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户