1346607-05-3|GSK621|CsnPharm

CAS No.: 1346607-05-3

GSK621 Catalog No. CSN19218

Synonyms: Gsk621

In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 AMPK

IC50:13-30µM
描述GSK621, a new thienopyridone deritate, is specific activator of AMPK that can activate ACC (S79) and ULK1 (S555) in MOLM-14 cells with IC50 of 30 μM^[2]. GSK621 could induce cytotoxicity (with a median IC50 of 20 µM) by activating autophagy independent of mTORC1. Moreover, the researchers also found that AMPK activation and constitutive activation of the mTORC1 signaling pathway have a lethal interaction in a series of AML primary samples and cell lines, while constitutively activated mTORC1 is absent in normal hematopoietic progenitors, so AMPK activation does not cause toxic effects on normal cells^[2]. There are also study demonstrate that GSK621 also can inhibit human melanoma cells A375 survival in both time- and concentration-dependent (1 μM – 3 μM) manners as well as pro-apoptotic activity^[3]. In vivo, GSK621 (30 mg/kg twice daily) decreased leukemia growth and significantly prolonged survival of xenograft tumor mouse^[4]. On the other hand, the oral administration of GSK621 inhibited the LPS-induced TNFα production and endotoxin shock in BALB/c mice^[5].
动物研究
剂量
Mice^[1] (i.p.): 10 mg/kg, 30 mg/kg

给药途径
i.p.

动物研究
剂量	Mice^[1] (i.p.): 10 mg/kg, 30 mg/kg
给药途径	i.p.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0412 mL
- 10.2060 mL
- 20.4120 mL
- 5 mM
- 0.4082 mL
- 2.0412 mL
- 4.0824 mL
- 10 mM
- 0.2041 mL
- 1.0206 mL
- 2.0412 mL

技术信息

CAS号

1346607-05-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H20ClN3O5

运输

蓝冰

分子量

489.91

别名

Gsk621

溶解度

DMSO	97.0 mg/mL (198.0 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

2% DMSO+30% PEG 300+5% Tween 80+water

5 mg/mL

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

GSK621 Catalog No. CSN19218

靶点选择性

请登录您的专属账户

确认信息