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CAS No.: 1628260-79-6

GLPG1690 Catalog No. CSN19695

GLPG1690, a first-in-class autotaxin (ATX) inhibitor with IC50 of 131 nM and Ki of 15 nMl, is able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice, and in reducing extra-cellular matrix deposition in the lung whilst also reducing LPA 18:2 content in bronchoalveolar lavage fluid and may be a possible effectvie compound in treating idiopathic pulmonary fibrosis.

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CAS号 1628260-79-6 储存条件
分子式 C30H33FN8O2S 运输 蓝冰
分子量 588.70 别名
溶解度
DMSO400 mg/mL (679.5 mM)
Waterinsoluble
动物实验配方

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