CAS No.: 16208-51-8
Dimesna/地美司钠 Catalog No. CSN10824
Synonyms: BNP-7787;mesna disulfide. US brand name: Tavocept. Abbreviation: DIM. Code name: BNP7787. Chemical structure name: 22dithiobisethanesulfonate disodium salt;地美司钠
Dimesna is a kidney selective prodrug to Mesna.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00003569 - - Completed - United States, Illinois ... more >> University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637-1470 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 Collapse << NCT00077311 Anemia Drug/A... more >>gent Toxicity by Tissue/Organ Lung Cancer Neutropenia Collapse << Phase 2 Completed - - NCT00039780 Breast Neoplasms ... more >> Breast Diseases Metastases, Neoplasm Collapse << Phase 3 Completed - - - 更多
- 参考文献
- [1] Parker AR, Petluru PN, et al. BNP7787-mediated modulation of paclitaxel- and cisplatin-induced aberrant microtubule protein polymerization in vitro. Mol Cancer Ther. 2010 Sep;9(9):2558-67.
- [2] Hausheer FH, Shanmugarajah D, et al. Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of gamma-glutamyl transpeptidase. Cancer Chemother Pharmacol. 2010 Apr;65(5):941-51.
- [3] Parker AR, Petluru PN, Wu M, Zhao M, Kochat H, Hausheer FH. BNP7787-mediated modulation of paclitaxel- and cisplatin-induced aberrant microtubule protein polymerization in vitro. Mol Cancer Ther. 2010;9(9):2558-2567.
- [4] Cutler MJ, Urquhart BL, Velenosi TJ, et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012;52(4):530-542.
- [5] Habs MR, Schmähl D. Prevention of urinary bladder tumors in cyclophosphamide-treated rats by additional medication with the uroprotectors sodium 2-mercaptoethane sulfonate (mesna) and disodium 2,2'-dithio-bis-ethane sulfonate (dimesna). Cancer. 1983;51(4):606-609.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 16208-51-8 | 储存条件 |
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| 分子式 | C4H8Na2O6S4 | 运输 | 蓝冰 | |||
| 分子量 | 326.34 | 别名 | BNP-7787;mesna disulfide. US brand name: Tavocept. Abbreviation: DIM. Code name: BNP7787. Chemical structure name: 22dithiobisethanesulfonate disodium salt;地美司钠;迪梅斯纳 | |||
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动物实验配方 |
